瞿昊博士以构建食品生物传感的分子识别材料体系为核心内容,围绕如何发掘、优化与利用识别材料的基础“方法学”问题进行了系统研究。截止目前已在国际著名期刊如J. Am. Chem. Soc., ACS Nano, Phys. Rev. X, J. Agric. Food Chem., ACS Sens., Biosens. Bioelectron., Food Chem.等上发表第一作者或通讯作者高质量论文20余篇。研究成果入选J. Am. Chem. Soc., J. Agric. Food Chem., Talanta等封面,并受到科技日报头版、中国科学报、安徽日报、中新网、新华网、人民网、Science Trends等重要媒体报道。先后承担国家自然科学基金面上和青年项目、科技部重点研发计划子课题、安徽省科技重大专项、安徽省自然科学基金、中央高校基本业务费校级专项等项目。于第三届、第四届中国核酸适配体学术研讨会做大会报告,并任第四届会议学术委员会成员。授权发明专利6件,参编国家标准2项。现任安徽省检验检测学会理事、Research期刊青年编委等。
代表性论文
第一作者论文:
1.Hao Qu, Manyi Zheng, Qihui Ma, Lu Wang, Yu Mao, Michael Eisenstein, Hyongsok Tom Soh*, Lei Zheng*, Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling, Angewandte Chemie International Edition, 2023, 62: e202214045.
2.Hao Qu*, Qihui Ma, Lu Wang, Yu Mao, Michael Eisenstein, Hyongsok Tom Soh*, Lei Zheng, Measuring Aptamer Folding Energy Using a Molecular Clamp, Journal of the American Chemical Society, 2020, 142(27): 11743-11749.(封面论文)
3.Hao Qu, Andrew T. Csordas, Jinpeng Wang, Seung Soo Oh, Michael S. Eisenstein, Hyongsok Tom Soh*, Rapid and Label-Free Strategy to Isolate Aptamers for Metal Ions, ACS Nano, 2016, 10(8): 7558-7565.
4.Hao Qu, Giovanni Zocchi*, How Enzymes Work: A Look through the Perspective of Molecular Viscoelastic Properties, Physical Review X, 2013, 3: 011009.
5.Hao Qu, Yong Wang, Chiao-Yu Tseng, Giovanni Zocchi*, Critical torque for kink formation in double stranded DNA, Physical Review X, 2011, 1: 021008.
6.Hao Qu, Lu Wang*, Jian Liu*, Lei Zheng*, Direct Screening for Cytometric Bead Assays for Adenosine Triphosphate, ACS Sensors, 2018, 3(10): 2071–2078.
通讯作者论文:
1.Songjia Luo#, Rongrong Wang#, Lu Wang#, Hao Qu*, Lei Zheng*, Breath alcohol sensor based on hydrogel-gated graphene field-effect transistor, Biosensors & Bioelectronics, 2022, 210: 114319.
2.Yuhong Wang, Hao Qu*, Rongrong Wang, Baolei Dong, Lei Zheng*, Label-Free Biosensing of Mercury(II) in Milk Using an Aptamer-Gated Graphene Field-Effect Transistor, Journal of Electroanalytical Chemistry, 2022, 904: 115931.
3.Rongrong Wang, Yong Cao, Hao Qu*, Yanbo Wang, Lei Zheng*, Label-free detection of Cu(II) in fish using a graphene field-effect transistor gated by structure-switching aptamer probes, Talanta, 2022, 237: 122965.(封面论文,featured article)
4.Yuhong Wang, Yulong Bi, Rongrong Wang, Lu Wang, Hao Qu*, and Lei Zheng, DNA-Gated Graphene Field-Effect Transistors for Specific Detection of Arsenic(III) in Rice, Journal of Agricultural and Food Chemistry, 2021, 69(4): 1398–1404.(封面论文)
5.Rongrong Wang, Yuhong Wang, Hao Qu*, Lei Zheng*, An Acetylcholinesterase-Functionalized Biosensor for Sensitive Detection of Organophosphorus Pesticides Based on Solution-Gated Graphene Transistors, ACS Agricultural Science & Technology, 2021, 1, 372–378.
6.Rongrong Wang, Yu Mao, Lu Wang, Hao Qu*, Ying Chen, Lei Zheng*, Solution-gated graphene transistor based sensor for histamine detection with gold nanoparticles decorated graphene and multi-walled carbon nanotube functionalized gate electrodes, Food Chemistry, 2021, 347: 128980.
7.Yu Mao, Shengjie Gao, Lili Yao, Lu Wang, Hao Qu*, Yuen Wu, Ying Chen, Lei Zheng*, Single-atom nanozyme enabled fast and highly sensitive colorimetric detection of Cr(VI), Journal of Hazardous Materials, 2021, 408: 124898.
8.Shengjie Gao, Rongrong Wang, Yulong Bi, Hao Qu*, Ying Chen, Lei Zheng*, Identification of frozen/thawed beef based on label-free detection of hemin (Iron Porphyrin) with solution-gated graphene transistor sensors, Sensors & Actuators: B. Chemical, 2020, 305: 127167.
9.Yulong Bi, Lihui Ye, Yu Mao, Lu Wang*, Hao Qu*, Jian Liu*, Lei Zheng*. Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for ultrasensitive and real-time detection of lactic acid from cancer cell metabolism, Biosensors & Bioelectronics, 2019, 140: 111271.
10.Rongrong Wang, Yu Mao, Hao Qu*, Wei Chen, Aijin Ma, Lei Zheng*, Highly sensitive and selective sulfite sensors based on solution-gated graphene transistors with multi-walled carbon nanotube functionalized gate electrodes, Food Chemistry, 2019, 290: 101-106.
11.Can Xiong, Tengfei Zhang, Di Wang, Yi Lin, Hao Qu*, Wei Chen, Linbao Luo, Yanbo Wang, Lei Zheng*, Linglin Fu*, Highly sensitive solution-gated graphene transistor based sensor for continuous and real-time detection of free chlorine, Analytica Chimica Acta, 2018, 1033: 65-72.
12.Can Xiong, Tengfei Zhang, Weiyu Kong, Zhixiang Zhang, Hao Qu*, Wei Chen, Yanbo Wang, Linbao Luo, Lei Zheng*, ZIF-67 derived porous Co3O4 hollow nanopolyhedron functionalized solution-gated graphene transistors for simultaneous detection of glucose and uric acid in tears, Biosensors & Bioelectronics, 2018, 101: 21-28.
13.Can Xiong#, Yang Wang#, Hao Qu*, Lijun Zhang, Longzhen Qiu, Wei Chen, Feng Yan, and Lei Zheng*, Highly sensitive detection of gallic acid based on organic electrochemical transistors with poly(diallyldimethylammonium chloride) and carbon nanomaterials nanocomposites functionalized gate electrodes, Sensors & Actuators: B. Chemical, 2017, 246: 235-242.
14.Can Xiong, Hao Qu*, Wei Chen, Lijun Zhang, Longzhen Qiu, Lei Zheng*, Fan Xia, Real-time detection of Cu(II) with PEDOT:PSS based organic electrochemical transistors, Science China Chemistry, 2017, 60(9): 1205–1211.
发明专利
1、一种快速检测牛肉冻融程度的方法,专利授权号:ZL201811643087.9.(第二发明人);
2、一种基于层状碳纳米片的酒精水凝胶传感设备及其方法,专利授权号:ZL202110052279.8(第二发明人)。
参编标准
1、国家标准,《核酸适配体体外筛选技术导则》,GB/T 38137-2019,2019-10-18发布实施;
2、国家标准,《核酸适配体亲和性和特异性评价技术导则》,GB/T 40187-2021,2021-05-21发布,2021-12-01实施。