报告:Neuropeptide Regulation of Synaptic Function in the Central Nervous System: Insights into Energy Homeostasis

报告时间：2025年07月18日（星期五）16:00-17:30

报告地点：食品与生物工程学院206会议室

报告 人：Zhiping Pang 教授

工作单位：Rutgers University

举办单位：食品与生物工程学院

报告简介：

Central glucagon-like peptide-1 (GLP-1), secreted by a distinct population of nucleus tractus solitarius neurons, suppresses feeding but the exact mechanisms of action in the brain remain unclear. Here, we investigate a descending circuit formed by GLP-1 receptor (GLP-1R) neurons in the paraventricular hypothalamic nucleus (PVNGLP-1R) projecting to the dorsal vagal complex (DVC) of the brain stem in mice. PVNGLP-1R→DVC synapses release glutamate and are augmented by GLP-1. Chemogenetic activation of PVNGLP-1R→DVC suppresses feeding. Under an energy deficit (that is, hunger) state, synaptic strength is weaker but is more profoundly augmented by GLP-1R activation than under energy-replete state. In an obese condition, the dynamic synaptic changes in this circuit are disrupted. Optogenetic activation of PVNGLP-1R→DVC projections suppresses food intake energy state dependently, and blocking its synaptic release or ablating GLP-1Rs in the presynaptic neurons impairs metabolic health. These findings indicate that the state-dependent synaptic regulation by GLP-1 in PVNGLP-1R→DVC descending circuit is important for energy homeostasis.

报告人简介：

Zhiping Pang, Henry Rutgers Professor of NeuroMetabolism, Dept. of Neuroscience and Cell Biology, RWJMS; and Director, Center for NeuroMetabolism. He studies the synaptic basis of the regulation of feeding, satiety, metabolism, and obesity. His lab aims to provide insights into the neural causes and consequences of childhood obesity. The research activity of the Pang Laboratory is funded by the National Institutes of Health (NIH), Brain and Behavior Research Foundation, US-Israel Binational Foundation, Sinsheimer Foundation, and the Robert Wood Johnson Foundation. Prof. Pang has published over a hundred research papers in top international academic journals such as Nature, Science, Nature Neuroscience, Nature Metabolism, Neuron, PNAS, Molecular Psychiatry.