1.泛素化肿瘤抑制因子p53 的化学合成及特异性去泛素化研究,国家自然科学基金面上项目,2019.01-2022.12, 参与;
2.毒素蛋白探针的化学合成及其生物学应用,国家自然科学基金面上项目,2016.01-2017.12, 参与;
3.转肽酶Sortase A催化的新反应及其在蛋白质修饰中的应用,国家自然科学基金面上项目,2014.01-2017.12, 参与;
代表性论文
(1)Shuai-Shuai Sun, Junyou Chen, Rui Zhao, Donald Bierer, Jun Wang*, Ge-Min Fang, Yi-Ming Li*. Efficient synthesis of a side-chain extended diaminodiacid for solid-phase synthesis of peptide disulfide bond mimics. Tetrahedron lett., 60 (2019):1197-1201
(2)Yang Xu, Yu Wang, Peiyuan Liu, Guo-Chao Chu, Hua-Jian Xu, Yi-Ming Li, Jun Wang*, Jing Shi*. Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents. Org. Biomol. Chem., 16 (2019):7036-7040
(3)Tao Wang, Yifu Kong, Yang Xu, Jian Fan, Hua-Jian Xu, Donald Bierer, Jun Wang*, Jing Shi, Yi-Ming Li*. Efficient synthesis of hydrocarbon-bridged diaminodiacids through nickel-catalyzed reductive cross-coupling. Tetrahedron lett., 8 (2017):3970-3973
(4)Chaojian Guan,Tao Wang,Jun Wang*,Yi-Ming Li*. Synthesis of Post-translational Modifier Protein NEDD8 via Ligation of Peptide Hydrazides, Chin. J. Org. Chem., 36(2016): 2763-2768
(5)Zhi-Peng Wang, Xiao-Zhe Ding, Jun Wang*,Yi-Ming Li*. Double-edged sword in cells: chemical biology studies of the vital role of cytochrome c in the intrinsic pre-apoptotic mitochondria leakage pathway. RSC Advance, 5 (2015): 28258-28269.
(6)Wei Li, Jun Wang*, Yu-Zhu Hu. Photo-degradation of fleroxacin injection:II. Kinetics and toxicological evaluation by the luminescent bacterium Q67[J]. AAPS Pham Scitech, 2013( 14): 578-586
(7)Jun Wang, Wei Li, Chen-Gui Li, and Yu-Zhu Hu*. Photodegradation of fleroxacin injection: different products with different concentration levels[J].AAPS Pham SciTech,2011:872-878.