颜玲-食品与生物工程学院

- 姓名：颜玲
- 职务：
- 职称：副研究员/硕导
- 所属系：食品生物技术系
- 邮箱：yanling602@hfut.edu.cn
- 办公地点：食生楼602

个人简介
研究领域
科研项目
学术成果
荣誉奖项

2012年6月毕业于安徽农业大学茶树生物学与资源利用国家重点实验室。2019年6月毕业于合肥工业大学获工学博士学位。2019.07.25-2021.10.8在合肥工业大学地质学流动站进行博士后研究工作。主要从事植物基农产品外泌体的开发与功能挖掘、食品活性因子传输体系设计与应用、肠道营养健康领域的研究工作。近年来，主持及参与国家自然科学基金、安徽省科技重大专项、博士后面上项目等多项项目。发表高质量论文20余篇（其中一篇入选Journal of Agricultural and Food Chemistry封面论文），授权发明专利4项

1.植物基农产品外泌体的开发与功能挖掘
2.食品活性因子传输体系设计与应用研究
3.肠道营养与健康的基础和应用研究

1.国家自然科学基金青年科学基金: 功能化壳聚糖载体增效槲皮素肠道吸收的机制及预测载体设计的新方法 (项目号32102128)，2022.01-2024.12，主持人
2.安徽省自然科学基金，2025.09-2028.09
3.中国博士后科学基金面上项目(项目号2019M662145)，2019.11-2021.09，主持人
4.合肥工业大学学术新人提升B计划资助项目: 光诱导生姜高效生产外泌体及其调控肠道微环境中巨噬细胞极化的分子机制, 2022.05-2024.05，主持人
5.安徽省精深加工重点实验室自主创新专项，2020.01-2021.12，主持人

论文
[1] Yan, L., Cao, Y., Hou, L., Luo, T., Li, M., Gao, S., Wang, L., Sheng, K*., Zheng, L*. Ginger exosome-like nanoparticle-derived miRNA therapeutics: A strategic inhibitor of intestinal inflammation. Journal of Advanced Research. 2025, 69: 1-15. （“ESI”高被引，热点论文）
[2] Luo, T., Hou, L., Cao, Y., Li, M., Sheng, X., Cheng, W., Yan, L*(通讯作者)., Zheng, L*. Tea extracellular vesicle-Derived microRNAs contribute to alleviate intestinal inflammation by reprogramming macrophages. Journal of Agricultural and Food Chemistry, 2025, 73(11):6745-6757.
[3]Yin, L., Yan, L*(通讯作者)., Yu, Q., Wang, J., Liu, C., Wang, L., Zheng, L*(通讯作者). Characterization of the microRNA profile of ginger exosome-like nanoparticles and their anti-inflammatory effects in intestinal Caco-2 cells. Journal of Agricultural and Food Chemistry. 2022, 70(15): 4725–4734.（“ESI”高被引）
[4] Cao, Y., Hou, L., Li, M., Zhang, J., Wang, L., Liu, C., Luo, T., Yan, L*(通讯作者)., Zheng, L*(通讯作者). Broccoli extracellular vesicles enhance the therapeutic effects and restore the chemosensitivity of 5-fluorouracil on colon cancer. Food and Chemical Toxicology. 2024, 186: 114563.
[5] Zheng, W., Wang W., Fu D., Zhang T., Liang Z., Yan, L*(通讯作者)., Liu C., & Zheng, L*(通讯作者) (2023). Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets. Food Research International. 164:112401.
[6] Yin, L., Yan, L*(通讯作者)., Yu, Q., Wang, J., Liu, C., Wang, L., & Zheng, L*(通讯作者). (2022). Characterization of the MicroRNA Profile of Ginger Exosome-like Nanoparticles and Their Anti-Inflammatory Effects in Intestinal Caco-2 Cells, Journal of Agricultural and Food Chemistry, 70(15), 4725-4734.
[7] Wang, J., Wei, L., Liu, C., Wang, L., Zheng, W., Shui, S., Yan, L*(通讯作者)., & Zheng, L*. (通讯作者) (2022). Taurine Treatment Alleviates Intestinal Mucositis Induced by 5-Fluorouracil in Mice, Plant Foods for Human Nutrition, 77(3):399-404.
[8]Yan, L#.,Zheng, H#., Liu, W., Liu, C*. Jin, T.Shui, S.,& Zheng, L*. (2021). UV-C treatment enhances organic acids and GABA accumulation in tomato fruits during storage. Food Chemistry, 338, 128126.
[9]Yan, L#., Wei, L#., Zheng, W., Liu, S., Yin, L., Liu, C*., & Zheng, L*.(2021).Oral Delivery of Chitosan Derivative-Based Nanoparticles Encapsulating Quercetin to Attenuate Intestinal Injury and Regulate Gut Microbiota Dysbiosis in Mucositis Treatment. ACS Food Science & Technology,1, 339-409.
[10]Liu, C., Jin, T., Wei, L., Hao, W.,Yan, L* (通讯作者).,& Zheng, L*(通讯作者). (2021). Preparation and physicochemical/antimicrobial characteristics of asparagus cellulose films containing quercetin. LWT-Food Science and Technology, 148, 111770.
[11] Yan, L.,Wang, L., Gao, S., Liu, C., Zhang, Z., Ma, A*., & Zheng, L*. (2020). Celery cellulose hydrogel as carriers for controlled release of short-chain fatty acid by ultrasound. Food Chemistry, 309, 125717.
[12] Yan, L#., Gao, S#., Shui, S., Liu, S., Qu, H., Liu, C., & Zheng, L*. (2020). Small interfering RNA-loaded chitosan hydrochloride/carboxymethyl chitosan nanoparticles for ultrasound-triggered release to hamper colorectal cancer growth in vitro. International Journal of Biological Macromolecules, 162(1), 1303-1310.
[13]Wei, L., Wang, J., Yan, L*(通讯作者)., Shui, S., Wang, L., Zheng, W., Liu, S., Liu, C., & Zheng, L*(通讯作者). (2020). Sulforaphane attenuates 5-fluorouracil induced intestinal injury in mice. Journal of Functional Foods, 69, 103965.
[14]Yan, L#., Wang, R#., Wang, H., Sheng, K., Liu, C., Qu, H., Ma, A., & Zheng, L*. (2018). Formulation and characterization of chitosan hydrochloride and carboxymethyl chitosan encapsulated quercetin nanoparticles for controlled applications in foods system and simulated gastrointestinal condition. Food Hydrocolloids, 84, 450-457.
[15]Yan, L., Xiong, C., Qu, H., Liu, C., Chen, W., & Zheng, L*. (2017). Non-destructive determination and visualisation of insoluble and soluble dietary fibre contents in fresh-cut celeries during storage periods using hyperspectral imaging technique. Food Chemistry, 228, 249-256.
专利
1.生姜外泌体样纳米颗粒中功能miRNA及其作为炎症抑制剂中的应用，申请号：202311012031.4
2.用于调节巨噬细胞极化的茶叶外泌体miRNA及获得方法和应用，申请号：202311015400.5
3.一种递送siRNA的壳聚糖衍生物纳米颗粒的制备方法，专利授权号：ZL 202010699292.
4.一种同时提高西兰花中萝卜硫素和吲哚-3-甲醇的方法及其制备的西兰花与应用，专利授权号：ZL 2022112531557.
5.一种基于近红外光谱分析技术的工夫红茶发酵质量的快速判别方法，专利授权号：ZL201410507679.3.

1. 博士研究生国家奖学金
2. 合肥工业大学本科毕业设计（论文）优秀指导教师（2023）
3. 指导学生获得“第八届全国大学生生命竞赛（创新创业类）”三等奖（2023）

职务：		职称：	副研究员/硕导
所属系：	食品生物技术系	邮箱：	yanling602@hfut.edu.cn
办公地点：	食生楼602	学术成果	<br>论文 <br>[1] Yan, L., Cao, Y., Hou, L., Luo, T., Li, M., Gao, S., Wang, L., Sheng, K., Zheng, L. Ginger exosome-like nanoparticle-derived miRNA therapeutics: A strategic inhibitor of intestinal inflammation. Journal of Advanced Research. 2025, 69: 1-15. （“ESI”高被引，热点论文） <br>[2] Luo, T., Hou, L., Cao, Y., Li, M., Sheng, X., Cheng, W., Yan, L(通讯作者)., Zheng, L. Tea extracellular vesicle-Derived microRNAs contribute to alleviate intestinal inflammation by reprogramming macrophages. Journal of Agricultural and Food Chemistry, 2025, 73(11):6745-6757. <br>[3]Yin, L., Yan, L(通讯作者)., Yu, Q., Wang, J., Liu, C., Wang, L., Zheng, L(通讯作者). Characterization of the microRNA profile of ginger exosome-like nanoparticles and their anti-inflammatory effects in intestinal Caco-2 cells. Journal of Agricultural and Food Chemistry. 2022, 70(15): 4725–4734.（“ESI”高被引） <br>[4] Cao, Y., Hou, L., Li, M., Zhang, J., Wang, L., Liu, C., Luo, T., Yan, L(通讯作者)., Zheng, L(通讯作者). Broccoli extracellular vesicles enhance the therapeutic effects and restore the chemosensitivity of 5-fluorouracil on colon cancer. Food and Chemical Toxicology. 2024, 186: 114563. <br>[5] Zheng, W., Wang W., Fu D., Zhang T., Liang Z., Yan, L(通讯作者)., Liu C., & Zheng, L(通讯作者) (2023). Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets. Food Research International. 164:112401. <br>[6] Yin, L., Yan, L(通讯作者)., Yu, Q., Wang, J., Liu, C., Wang, L., & Zheng, L(通讯作者). (2022). Characterization of the MicroRNA Profile of Ginger Exosome-like Nanoparticles and Their Anti-Inflammatory Effects in Intestinal Caco-2 Cells, Journal of Agricultural and Food Chemistry, 70(15), 4725-4734. <br>[7] Wang, J., Wei, L., Liu, C., Wang, L., Zheng, W., Shui, S., Yan, L(通讯作者)., & Zheng, L. (通讯作者) (2022). Taurine Treatment Alleviates Intestinal Mucositis Induced by 5-Fluorouracil in Mice, Plant Foods for Human Nutrition, 77(3):399-404. <br>[8]Yan, L#.,Zheng, H#., Liu, W., Liu, C. Jin, T.Shui, S.,& Zheng, L. (2021). UV-C treatment enhances organic acids and GABA accumulation in tomato fruits during storage. Food Chemistry, 338, 128126. <br>[9]Yan, L#., Wei, L#., Zheng, W., Liu, S., Yin, L., Liu, C., & Zheng, L.(2021).Oral Delivery of Chitosan Derivative-Based Nanoparticles Encapsulating Quercetin to Attenuate Intestinal Injury and Regulate Gut Microbiota Dysbiosis in Mucositis Treatment. ACS Food Science & Technology,1, 339-409. <br>[10]Liu, C., Jin, T., Wei, L., Hao, W.,Yan, L* (通讯作者).,& Zheng, L(通讯作者). (2021). Preparation and physicochemical/antimicrobial characteristics of asparagus cellulose films containing quercetin. LWT-Food Science and Technology, 148, 111770. <br>[11] Yan, L.,Wang, L., Gao, S., Liu, C., Zhang, Z., Ma, A., & Zheng, L. (2020). Celery cellulose hydrogel as carriers for controlled release of short-chain fatty acid by ultrasound. Food Chemistry, 309, 125717. <br>[12] Yan, L#., Gao, S#., Shui, S., Liu, S., Qu, H., Liu, C., & Zheng, L. (2020). Small interfering RNA-loaded chitosan hydrochloride/carboxymethyl chitosan nanoparticles for ultrasound-triggered release to hamper colorectal cancer growth in vitro. International Journal of Biological Macromolecules, 162(1), 1303-1310. <br>[13]Wei, L., Wang, J., Yan, L(通讯作者)., Shui, S., Wang, L., Zheng, W., Liu, S., Liu, C., & Zheng, L(通讯作者). (2020). Sulforaphane attenuates 5-fluorouracil induced intestinal injury in mice. Journal of Functional Foods, 69, 103965. <br>[14]Yan, L#., Wang, R#., Wang, H., Sheng, K., Liu, C., Qu, H., Ma, A., & Zheng, L. (2018). Formulation and characterization of chitosan hydrochloride and carboxymethyl chitosan encapsulated quercetin nanoparticles for controlled applications in foods system and simulated gastrointestinal condition. Food Hydrocolloids, 84, 450-457. <br>[15]Yan, L., Xiong, C., Qu, H., Liu, C., Chen, W., & Zheng, L. (2017). Non-destructive determination and visualisation of insoluble and soluble dietary fibre contents in fresh-cut celeries during storage periods using hyperspectral imaging technique. Food Chemistry, 228, 249-256. <br>专利 <br>1.生姜外泌体样纳米颗粒中功能miRNA及其作为炎症抑制剂中的应用，申请号：202311012031.4 <br>2.用于调节巨噬细胞极化的茶叶外泌体miRNA及获得方法和应用，申请号：202311015400.5 <br>3.一种递送siRNA的壳聚糖衍生物纳米颗粒的制备方法，专利授权号：ZL 202010699292. <br>4.一种同时提高西兰花中萝卜硫素和吲哚-3-甲醇的方法及其制备的西兰花与应用，专利授权号：ZL 2022112531557. <br>5.一种基于近红外光谱分析技术的工夫红茶发酵质量的快速判别方法，专利授权号：ZL201410507679.3.
研究领域	<br>1.植物基农产品外泌体的开发与功能挖掘 <br>2.食品活性因子传输体系设计与应用研究 <br>3.肠道营养与健康的基础和应用研究	科研项目	<br>1.国家自然科学基金青年科学基金: 功能化壳聚糖载体增效槲皮素肠道吸收的机制及预测载体设计的新方法 (项目号32102128)，2022.01-2024.12，主持人 <br>2.安徽省自然科学基金，2025.09-2028.09 <br>3.中国博士后科学基金面上项目(项目号2019M662145)，2019.11-2021.09，主持人 <br>4.合肥工业大学学术新人提升B计划资助项目: 光诱导生姜高效生产外泌体及其调控肠道微环境中巨噬细胞极化的分子机制, 2022.05-2024.05，主持人 <br>5.安徽省精深加工重点实验室自主创新专项，2020.01-2021.12，主持人
荣誉奖项	<br>1. 博士研究生国家奖学金 <br>2. 合肥工业大学本科毕业设计（论文）优秀指导教师（2023） <br>3. 指导学生获得“第八届全国大学生生命竞赛（创新创业类）”三等奖（2023）

副教授