副教授

    • 姓名:穆冬冬
    • 职务:
    • 职称:副教授、博士生导师
    • 所属系:食品质量安全系
    • 邮箱:d.mu@hfut.edu.cn
    • 办公地点:翡翠湖校区食品与生物工程学院
  • 个人简介
  • 研究领域
  • 科研项目
  • 学术成果
  • 荣誉奖项

2003年09月-2007年07月,重庆大学,本科

2007年09月-2010年07月,重庆大学,硕士,导师:殷幼平教授

2010年11月-2015年09月,荷兰格罗宁根大学(Rijkuniversiteit Groningen/University of Groningen),博士,导师:Oscar P. Kuipers教授(荷兰皇家科学院院士)

2016年01月-2021年12月,合肥工业大学,讲师

2021年12月-至今,合肥工业大学,副教授

职务: 职称: 副教授、博士生导师
所属系: 食品质量安全系 邮箱: d.mu@hfut.edu.cn
办公地点: 翡翠湖校区食品与生物工程学院 学术成果 <br>一、代表性论文(*通讯作者;#共同一作)
<br>2025
<br>24. Mu D*, Wang D*, Montalbán-López M, Wu X, Li X*. Enhancement of Thermostability and Catalytic Activity of β-1,4-Xylanase via Rational and Semi-rational Collaborative Engineering. Journal of Agricultural and Food Chemistry. 2025, 73(45):28946-28964.
<br>23. Zhang X, Montalbán-López M, Li X, Wu X, Mu D*. Metabolic Engineering of Lactococcus lactis for the Enhanced Production of Lactate by Manipulating Pyruvate Dehydrogenase Complex E2 and Lactate Dehydrogenase. Journal of Agricultural and Food Chemistry. 2025, 73(40):25549-25561.
<br>22. Ai Y, Montalbán-López M, Li P, Zhang H, Wu X, Li X*, Mu D*. Semirational Design and Immobilization Synergistically Enhance Barnase Activity and Stability. Journal of Agricultural and Food Chemistry. 2025, 73(16):9743-9758.
<br>2024
<br>21. Ma T, Li X, Montalbán-López M, Wu X, Zheng Z*, Mu D*. Effect of the Membrane Insertase YidC on the Capacity of Lactococcus lactis to Secret Recombinant Proteins. Journal of Agricultural and Food Chemistry. 2024, 72, 23320−23332.
<br>20. Wei D, Ma T, Montalbán-López M, Li X, Wu X, Mu D*. Enhanced Production, Enzymatic Activity, and Thermostability of an α-Amylase from Bacillus amyloliquefaciens in Lactococcus lactis. Journal of Agricultural and Food Chemistry. 2024, 72, 24587−24598.
<br>19. Ai Y#, Kang N#, Montalbán-López M, Wu X, Li X*, Mu D*. Enhanced stability, quality and flavor of bread through sourdough fermentation with nisin-secreting Lactococcus lactis NZ9700. Food Bioscience. 62 (2024) 105484.
<br>18. Mu D#*, Li P#, Ma T#, Wei D#, Montalbán-López M, Ai Y, Wu X, Wang Y, Li X, Li X*. Advances in the understanding of the production, modification and applications of xylanases in the food industry. Enzyme and Microbial Technology. 2024 Sep:179:110473.
<br>2023
<br>17. Ai Y, Li X, Wu X, Montalbán-López M, Zheng Z, Mu D*. Secreting recombinant barnase by Lactococcus lactis and its application in reducing RNA from forages. Enzyme and Microbial Technology. 2023 Mar;164:110191.
<br>2022
<br>16. Ma T, Li X, Montalbán-López M, Wu X, Zheng Z*, Mu D*. Secretion of Bacillus amyloliquefaciens Transglutaminase from Lactococcus lactis and Its Enhancement of Food Gel Properties. Gels. 2022, 8, 674.
<br>15. Bao S, Li X, Wu X, Montalbán-López M, Qiao M, Zheng Z, Cai J, and Mu D*. Secretion of Bacillus amyloliquefaciens Levansucrase and Its Mutants from L. lactis NZ9000 and Their Applications in the Synthesis of Levan. ACS Food Science & Technology. 2022, 2, 4, 655-666.
<br>2021
<br>14. Ma T, Li X, Wu X, Jiang S, Zheng Z* and Mu D*. Expression of Bacillus amyloliquefaciens γ-glutamyltransferase in Lactococcus lactis and immobilization on magnetic nanoparticles. ACS Food Science & Technology. 2021, 1, 5, 778-787.
<br>13. Mu D*, Zhou Y, Wu X, Montalban-Lopez M, Wang L, Li X, and Zheng Z. Secretion of Bacillus amyloliquefaciens Levansucrase from Bacillus subtilis and Its Application in the Enzymatic Synthesis of Levan. ACS Food Science & Technology. 2021, 1, 2, 249-259.
<br>2020
<br>12. Mu D, Li H, Li X, Zhu J, Qiao M, Wu X, Luo S, Yang P, Zhao Y, Liu F, Jiang S, Zheng Z*. Enhancing laccase-induced soybean protein isolates gel properties by microwave pretreatment, Journal of Food Processing and Preservation. 2020, 44(4): e14386.
<br>2019
<br>11. Mu D*#, Li H#, Chen Q#, Zhu J, Wu X, Luo S, Zhao Y, Wang L, Jiang S, Li X*, Zheng Z*. Secretion of Bacillus amyloliquefaciens γ-Glutamyltranspeptidase from Bacillus subtilis and its application in enzymatic synthesis of l-theanine, Journal of Agricultural and Food Chemistry. 2019, 67(51):14129-14136.
<br>10. Ma T#, Lu J#, Zhu J#, Li X, Gu H, Montalbán-López M, Wu X, Luo S, Zhao Y, Jiang S, Zheng Z*, Mu D*. The secretion of Streptomyces monbaraensis transglutaminase from Lactococcus lactis and immobilization on porous magnetic nanoparticles, Frontiers in Microbiology. 2019, 10:1675.
<br>2018
<br>9. Mu D*#, Lu J#, Qiao M, Kuipers OP, Zhu J, Li X, Yang P, Zhao Y, Luo S, Wu X, Jiang S, Zheng Z. Heterologous signal peptides-directing secretion of Streptomyces mobaraensis transglutaminase by Bacillus subtilis, Applied Microbiology and Biotechnology, 2018. 102(13):5533-5543.
<br>8. Mu D, Lu J, Shu C, Li H, Li X, Cai J, Luo S, Yang P, Jiang S, Zheng Z. Improvement of the activity and thermostability of microbial transglutaminase by multiple-site mutagenesis, Bioscience Biotechnology & Biochemistry, 2018, 82:1, 106-109.
<br>2017
<br>7. Wang K, Li C, Wang B, Yang W, Luo S, Zhao Y, Jiang S, Mu D*, Zheng Z*. Formation of macromolecules in wheat gluten/starch mixtures during twin-screw extrusion: effect of different additives. Journal of the Science of Food and Agriculture. 2017 Dec; 97(15):5131-5138. doi: 10.1002/jsfa.8392.
<br>2016
<br>6. Alvarez-Sieiro P, Montalbán-López M, Mu D, Kuipers OP*, Bacteriocins of lactic acid bacteria: extending the family, Applied Microbiology and Biotechnology, 2016 100(7): 2939-2951.
<br>2015
<br>5. Mu D, Montalbán-López M, Deng J, Kuipers OP*, Lantibiotic reductase LtnJ substrate selectivity assessed with a collection of nisin derivatives as substrates, Applied and Environmental Microbiology, 2015, 81(11):3679-3687.
<br>2013
<br>4. Mu D, Montalbán-López M, Masuda Y, Kuipers OP*, Zirex: a novel zinc-regulated expression system for Lactococcus lactis, Applied and Environmental Microbiology, 2013, 79(14):4503-4508.
<br>3. van Heel AJ#, Mu D#, Montalbán-López M, Hendriks D, Kuipers OP*, Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes, ACS Synthetic Biology, 2013, 2(7): 397-404.
<br>2011
<br>2. Yin Y, Mu D*, Chen S, Liu L, Wang Z*, Effects on growth and digestive enzyme activities of the Hepialus gonggaensis larvae caused by introducing probiotics, World Journal of Microbiology and Biotechnology, 2011, 27(3): 529-533.
<br>2010
<br>1. 穆冬冬,王中康,殷幼平,饲喂肉杆菌Hg4-03对贡嘎蝠蛾幼虫肠菌生物多样性的影响,微生物学报,2010,50 (02).
<br>二、授权专利
<br>1.一种β-1,4-木聚糖酶突变体及其构建方法,专利号:ZL 202511095123.2
研究领域 <br>1.食品微生物合成生物学
<br>2.食品酶在微生物中的发酵生产
<br>3.活性功能物质在微生物中的分泌机制
<br>4.食品酶的功能与结构研究
<br>5.食品酶在食品加工过程中的应用
<br>6.微生物抗菌多肽的生物合成与修饰
<br>开设课程
<br>专业课:《食品酶学》、《食品卫生学》、《生物工程专业英语》、《生物技术专业英语》
<br>公选课:《遗传学发现》、《生物安全》
科研项目 <br>1.国家自然科学基金面上项目(32472299),2025.01-2028.12,项目负责人。
<br>2.国家重点研发计划项目子课题(2025YFF1107300),子课题负责人。
<br>3.中国博士后科学基金(2019M651013),2019.07-2022.06,项目负责人。
<br>4.安徽省科技重大专项(201903a06020007),2019.09-2022.08,项目负责人。
<br>5.安徽省自然科学基金面上项目(2408085MC082),2025.01-2027.12,项目负责人。
<br>6.安徽省自然科学基金面上项目(2108085MC123),2021.01-2023.12,项目负责人。
<br>7.安徽省自然科学基金青年项目(1708085QC65),2017.01-2019.12,项目负责人。
<br>8.横向项目(W2024JSFW0924),2024.10-2027.10,项目负责人。
<br>9.横向项目(W2023JSKF0788),2023.11-2025.10,项目负责人。
<br>10.横向项目(W2022JSFW0296),2022.01-2024.12,项目负责人。
<br>11.横向项目(W2021JSKF1070),2021.01-2023.12,项目负责人。
<br>12.横向项目(W2020JSKF0538),2020.01-2023.12,项目负责人。
<br>13.中央高校博士专项科研资助基金(JZ2016HGBZ0777),2017.01-2018.12,项目负责人。
<br>14.中央高校博士专项科研资助基金(PA2021KCPY0048),2021.01-2022.12,项目负责人。
<br>15.安徽省重点实验室自主创新专项(PA2019GDPK0063),2019.01-2020.12,项目负责人。
<br>16.茶树生物学与资源利用国家重点实验室开放基金(SKLTOF20180107),2018.01-2019.12,项目负责人。
荣誉奖项 <br>1.安徽省食品创新设计大赛一等奖(2020)、二等奖(2021)、三等奖(2018、2020)
<br>2.安徽省食品创新设计大赛优秀指导教师(2020)
<br>3.安徽省科技进步一等奖(R9)(2025)
<br>4.合肥工业大学毕业设计优秀指导教师(2025)

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