张爽-食品与生物工程学院

- 姓名：张爽
- 职务：
- 职称：副教授、硕导
- 所属系：药物科学与工程系
- 邮箱：zhangshuang@hfut.edu.cn
- 办公地点：食品与生物工程学院507

个人简介
研究领域
科研项目
学术成果
荣誉奖项

学习经历：

1、2011年9月-2015年6月，毕业院校：中国海洋大学海洋生命学院（生命基地班），学历：大学本科

2、2015年9月-2020年6月，毕业院校：南开大学生生命科学学院，学历：博士研究生

工作经历：

2020年12月-至今，合肥工业大学食品与生物工程学院，副教授、硕导

研究方向：代谢疾病（肝脏疾病、心血管疾病）的药理学和分子机理研究。
招生方向：欢迎对基础医学和代谢疾病、药理学和分子靶点研究方向感兴趣的生物学、生物技术、药学、生物信息学、食品科学等相关专业的同学报考硕士研究生，一起发现疾病领域的未知。

1.国家自然科学基金青年项目，在研，主持。
2.安徽省自然科学基金青年项目，在研，主持。
3.合肥工业大学学术新人提升计划A项目，结题，主持。
4.合肥工业大学学术新人提升计划B项目，在研，主持。
5.企业合作委托项目，编号W2022JSFW0781，在研，主持。
6.企业合作委托项目，编号W2022JSFW0883，在研，主持。
7.产学研合作项目，编号W2023JSFW0071，在研，主持。
8.产学研合作项目，编号W2023JSFW0567，在研，主持。
9.复方中药创新数智研发，编号W2024JSFW0169，在研，主持。

代表性论文：
1.Shuang Zhang, Fangling Guo, Miao Yu, Xiaoxiao Yang, Zhi Yao, Qi Li, Zhuo Wei, Ke Feng, Peng Zeng, Dan Zhao, Xiaoju Li, Yan Zhu, Qing Robert Miao, Yasuko Iwakiri, Yuanli Chen*, Jihong Han*, Yajun Duan*. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol. 2020 Dec;73(6):1482-1495.
2.Jiaqi Li#, Shuang Zhang#, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan. Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring. EMBO Rep. 2024.
3.Shuang Zhang#, Miao Yu#, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han*, Yajun Duan*. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14-PGJ2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060.
4.Miao Yu#, Shuang Zhang#, Fangling Guo, Xiaoxiao Yang, Qi Li, Zhuo Wei, Jihong Han*, Yajun Duan*, Yuanli Chen*. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signal. 2020 Jan;65:109429.
5.Zequn Yin#, Xuerui Wang#, Shihong Zheng, Peichang Cao, Yuanli Chen, Maoyun Yu, Chenzhong Liao, Zhongyuan Zhang, Jihong Han, Yajun Duan, Xiaoxiao Yang*, Shuang Zhang*. LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation. Front Aging Neurosci. 2020 Nov 23;12:582455.
6.Xuerui Wang#, Zequn Yin#, Peichang Cao, Shihong Zheng, Yuanli Chen, Maoyun Yu, Chenzhong Liao,Zhongyuan Zhang, Yajun Duan, Jihong Han, Shuang Zhang*, Xiaoxiao Yang*. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomed Pharmacother. 2021 Jan;133:110964.
7.Xuerui Wang, Zequn Yin, Xianshe Meng, Daigang Yang, Huawen Meng, Chenzhong Liao, Lingling Wei, Yuanli Chen, Xiaoxiao Yang, Jihong Han, Yajun Duan*, Shuang Zhang*. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice. J Funct Foods. 92 (2022) 105060.
8.Huaxin Li#, Mengxue Zhang#, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan*, Shuang Zhang*. Daidzein alleviates Doxorubicin-induced heart failure via SIRT3/FOXO3a signaling pathway. Food Funct. 2022 Sep 22;13(18):9576-9588.
9.Feng Zhang#, Mengyao Wang#, Yang Zha, Jie Zhou, Jihong Han*, Shuang Zhang*. Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-kB/NLRP3 Inflammasome Pathway. Nutrients. 2023 Jan 1;15(1):223.
10.Yuanli Chen, Shu Yang, Lipei Liu, Xiaoxiao Yang, Yajun Duan, Shuang Zhang*, Jihong Han*. A novel therapy for hepatic cholestasis treatment—the combination of rosiglitazone and fenofibrate. Eur J Pharmacol. 2023 Jan 5:938:175428.
11.Miao Yu, Meixiu Jiang, Yuanli Chen, Shuang Zhang, Wenwen Zhang, Xiaoxiao Yang, Xiaoju Li, Yan Li, Shengzhong Duan, Jihong Han, Yajun Duan. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89.
12.Qi Li, Yi Chen, Dan Zhao, Zhuo Wei, Shuang Zhang, Yuanli Chen, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Xiumei Gao, Pengzhi Dong, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol. 2018 Jul;72(1):49-59.
13.Qi Li, Yi Chen, Dan Zhao, Shu Yang, Shuang Zhang, Zhuo Wei, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 2019 Jun;144:167-180.
14.Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol. 2019 Feb;73(2):105-117.
15.Zhuo Wei, Dan Zhao, Ye Zhang, Yuanli Chen, Shuang Zhang, Qi Li, Peng Zeng, Xiaoju Li, Wenwen Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner. Biochem Biophys Res Commun. 2019 Nov 19;519(4):854-860.
16.Dan Zhao, Chao Xue, Jiaqi Li, Ke Feng, Peng Zeng, Yuanli Chen, Yajun Duan, Shuang Zhang, Xiaoju Li, Jihong Han, Xiaoxiao Yang. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020 Dec 10;533(3):304-312.
17.Ke Feng, Chuanrui Ma, Yuxin Liu, Xiaoxiao Yang, Zhimou Yang, Yaoxia Chen, Tengyan Xu, Chengbiao Yang, Shuang Zhang, Qi Li, Zhuo Wei, Dan Zhao, Peng Zeng, Jihong Han, Jie Gao, Yuanli Chen, Yajun Duan. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR- induced lipogenesis. Theranostics. 2021 Jan 1;11(6):2634-2654.
18.Yingquan Liang, Guilan Chen, Feng Zhang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan, Maoyun Yu, Shuang Zhang, Jihong Han. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (Basel). 2021 Jun 5;10(6):916.
19.Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food Funct. 2021 Mar 15;12(5):2323-2334.
20.Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624.
21.Buchun Zhang, Rong Huang, Daigang Yang, Guilan Chen, Yuanli Chen, Jihong Han, Shuang Zhang, LiKun Ma, XiaoXiao Yang. Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. Oxid Med Cell Longev. 2022 Jan 17;2022:3087198.
22.Xiaolin Wang, Yanfang Yang, Dan Zhao, Shuang Zhang, Yi Chen, Yuanli Chen, Ke Feng, Xiaoju Li, Jihong Han, Yasuko Iwakiri, Yajun Duan, Xiaoxiao Yang. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. J Biol Chem. 2022 Feb;298(2):101561.
23.Yali Yan, Mengmeng Zhu, Jialing Ma, Xiaoyu He, Xiaoxiao Yang, Hongmei Xu, Meixiu Jiang, Shuang Zhang, Yajun Duan, Jihong Han, Yuanli Chen. MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. Bioengineered. 2022 Apr;13(4):11214-11227.
24.Dan Zhao, Chao Xue, Yanfang Yang, Jiaqi Li, Xiaolin Wang, Yi Chen, Shuang Zhang, Yuanli Chen, Yajun Duan, Xiaoxiao Yang, Jihong Han. Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Biomed Pharmacother. 2022 Sep:153:113444.
25.Xiaoyu He, Mengmeng Zh, Juan Zheng, Chengyi Wang, Xiaokang Zhao, Baotong Zhang, Dachen Zhou, Shuang Zhang, Xiaoxiao Yang, Yajun Duan, Jihong Han, Yuanli Chen. Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression. Acta Pharmacol Sin. 2023 Mar;44(3):635-646.
26.Juan Zheng, Shengnan Wang, Tingting Zhang, Huaxin Li, Mengmeng Zhu, Xiaoning Wei, Yu Ge, Xiaoxiao Yang, Shuang Zhang, Hongmei Xu, Yajun Duan, Lipei Liu, Yuanli Chen. Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway. Int Immunopharmacol. 2023 Jul:120:110378.
27.Huawen Meng, Zhenbao Shen, Xianshe Meng, Leng Wei, Zequn Yin, Xuerui Wang, Ting-Feng Zou, Zhigang Liu, Tianxiang Wang, Shuang Zhang, Yuanli Chen, Xiaoxiao Yang, Qingshan Li, Yajun Duan. Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway. Bioorg Chem. 2023 Sep:138:106654.
专利：
1.治疗葡萄糖和或脂质代谢紊乱的药物和治疗葡萄糖和或脂质代谢紊乱的方法（美国专利），专利授权号：132257-00102.
2.Nogo-B抑制剂在制备治疗糖脂代谢紊乱药物中的应用和治疗糖脂代谢紊乱的药物，公开。

1.2018年中华医学科学技术奖三等奖“动脉粥样硬化干预靶点与机制研究”。
2.2018年第十四届全国脂质与脂蛋白学术会议青年优秀论文大赛奖。
3.2018年美国Experimental Biology 2018学术会议 ASBMB Travel Award。
4.2019年动脉粥样硬化干预靶点与机制研究中华医学会科技奖三等奖。
5.2019年南开大学博士研究生国家奖学金、博士研究生一等奖学金。
6.2020年安徽省细胞生物学会口头报告一等奖。
7.2022年安徽省病理生理学心血管疾病专业委员会优秀墙报特等奖。

职务：		职称：	副教授、硕导
所属系：	药物科学与工程系	邮箱：	zhangshuang@hfut.edu.cn
办公地点：	食品与生物工程学院507	学术成果	<br>代表性论文： <br>1.Shuang Zhang, Fangling Guo, Miao Yu, Xiaoxiao Yang, Zhi Yao, Qi Li, Zhuo Wei, Ke Feng, Peng Zeng, Dan Zhao, Xiaoju Li, Yan Zhu, Qing Robert Miao, Yasuko Iwakiri, Yuanli Chen, Jihong Han, Yajun Duan. Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. J Hepatol. 2020 Dec;73(6):1482-1495. <br>2.Jiaqi Li#, Shuang Zhang#, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan. Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring. EMBO Rep. 2024. <br>3.Shuang Zhang#, Miao Yu#, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han, Yajun Duan. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14-PGJ2 and Nogo. Br J Pharmacol. 2020 Mar;177(5):1041-1060. <br>4.Miao Yu#, Shuang Zhang#, Fangling Guo, Xiaoxiao Yang, Qi Li, Zhuo Wei, Jihong Han, Yajun Duan, Yuanli Chen. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signal. 2020 Jan;65:109429. <br>5.Zequn Yin#, Xuerui Wang#, Shihong Zheng, Peichang Cao, Yuanli Chen, Maoyun Yu, Chenzhong Liao, Zhongyuan Zhang, Jihong Han, Yajun Duan, Xiaoxiao Yang, Shuang Zhang. LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation. Front Aging Neurosci. 2020 Nov 23;12:582455. <br>6.Xuerui Wang#, Zequn Yin#, Peichang Cao, Shihong Zheng, Yuanli Chen, Maoyun Yu, Chenzhong Liao,Zhongyuan Zhang, Yajun Duan, Jihong Han, Shuang Zhang, Xiaoxiao Yang. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. Biomed Pharmacother. 2021 Jan;133:110964. <br>7.Xuerui Wang, Zequn Yin, Xianshe Meng, Daigang Yang, Huawen Meng, Chenzhong Liao, Lingling Wei, Yuanli Chen, Xiaoxiao Yang, Jihong Han, Yajun Duan, Shuang Zhang. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice. J Funct Foods. 92 (2022) 105060. <br>8.Huaxin Li#, Mengxue Zhang#, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang. Daidzein alleviates Doxorubicin-induced heart failure via SIRT3/FOXO3a signaling pathway. Food Funct. 2022 Sep 22;13(18):9576-9588. <br>9.Feng Zhang#, Mengyao Wang#, Yang Zha, Jie Zhou, Jihong Han, Shuang Zhang. Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-kB/NLRP3 Inflammasome Pathway. Nutrients. 2023 Jan 1;15(1):223. <br>10.Yuanli Chen, Shu Yang, Lipei Liu, Xiaoxiao Yang, Yajun Duan, Shuang Zhang, Jihong Han. A novel therapy for hepatic cholestasis treatment—the combination of rosiglitazone and fenofibrate. Eur J Pharmacol. 2023 Jan 5:938:175428. <br>11.Miao Yu, Meixiu Jiang, Yuanli Chen, Shuang Zhang, Wenwen Zhang, Xiaoxiao Yang, Xiaoju Li, Yan Li, Shengzhong Duan, Jihong Han, Yajun Duan. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89. <br>12.Qi Li, Yi Chen, Dan Zhao, Zhuo Wei, Shuang Zhang, Yuanli Chen, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Xiumei Gao, Pengzhi Dong, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice. J Cardiovasc Pharmacol. 2018 Jul;72(1):49-59. <br>13.Qi Li, Yi Chen, Dan Zhao, Shu Yang, Shuang Zhang, Zhuo Wei, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells. Pharmacol Res. 2019 Jun;144:167-180. <br>14.Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang. LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation. J Cardiovasc Pharmacol. 2019 Feb;73(2):105-117. <br>15.Zhuo Wei, Dan Zhao, Ye Zhang, Yuanli Chen, Shuang Zhang, Qi Li, Peng Zeng, Xiaoju Li, Wenwen Zhang, Yajun Duan, Jihong Han, Xiaoxiao Yang. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner. Biochem Biophys Res Commun. 2019 Nov 19;519(4):854-860. <br>16.Dan Zhao, Chao Xue, Jiaqi Li, Ke Feng, Peng Zeng, Yuanli Chen, Yajun Duan, Shuang Zhang, Xiaoju Li, Jihong Han, Xiaoxiao Yang. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020 Dec 10;533(3):304-312. <br>17.Ke Feng, Chuanrui Ma, Yuxin Liu, Xiaoxiao Yang, Zhimou Yang, Yaoxia Chen, Tengyan Xu, Chengbiao Yang, Shuang Zhang, Qi Li, Zhuo Wei, Dan Zhao, Peng Zeng, Jihong Han, Jie Gao, Yuanli Chen, Yajun Duan. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR- induced lipogenesis. Theranostics. 2021 Jan 1;11(6):2634-2654. <br>18.Yingquan Liang, Guilan Chen, Feng Zhang, Xiaoxiao Yang, Yuanli Chen, Yajun Duan, Maoyun Yu, Shuang Zhang, Jihong Han. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (Basel). 2021 Jun 5;10(6):916. <br>19.Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang. Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis. Food Funct. 2021 Mar 15;12(5):2323-2334. <br>20.Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. <br>21.Buchun Zhang, Rong Huang, Daigang Yang, Guilan Chen, Yuanli Chen, Jihong Han, Shuang Zhang, LiKun Ma, XiaoXiao Yang. Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. Oxid Med Cell Longev. 2022 Jan 17;2022:3087198. <br>22.Xiaolin Wang, Yanfang Yang, Dan Zhao, Shuang Zhang, Yi Chen, Yuanli Chen, Ke Feng, Xiaoju Li, Jihong Han, Yasuko Iwakiri, Yajun Duan, Xiaoxiao Yang. Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms. J Biol Chem. 2022 Feb;298(2):101561. <br>23.Yali Yan, Mengmeng Zhu, Jialing Ma, Xiaoyu He, Xiaoxiao Yang, Hongmei Xu, Meixiu Jiang, Shuang Zhang, Yajun Duan, Jihong Han, Yuanli Chen. MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. Bioengineered. 2022 Apr;13(4):11214-11227. <br>24.Dan Zhao, Chao Xue, Yanfang Yang, Jiaqi Li, Xiaolin Wang, Yi Chen, Shuang Zhang, Yuanli Chen, Yajun Duan, Xiaoxiao Yang, Jihong Han. Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization. Biomed Pharmacother. 2022 Sep:153:113444. <br>25.Xiaoyu He, Mengmeng Zh, Juan Zheng, Chengyi Wang, Xiaokang Zhao, Baotong Zhang, Dachen Zhou, Shuang Zhang, Xiaoxiao Yang, Yajun Duan, Jihong Han, Yuanli Chen. Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression. Acta Pharmacol Sin. 2023 Mar;44(3):635-646. <br>26.Juan Zheng, Shengnan Wang, Tingting Zhang, Huaxin Li, Mengmeng Zhu, Xiaoning Wei, Yu Ge, Xiaoxiao Yang, Shuang Zhang, Hongmei Xu, Yajun Duan, Lipei Liu, Yuanli Chen. Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway. Int Immunopharmacol. 2023 Jul:120:110378. <br>27.Huawen Meng, Zhenbao Shen, Xianshe Meng, Leng Wei, Zequn Yin, Xuerui Wang, Ting-Feng Zou, Zhigang Liu, Tianxiang Wang, Shuang Zhang, Yuanli Chen, Xiaoxiao Yang, Qingshan Li, Yajun Duan. Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway. Bioorg Chem. 2023 Sep:138:106654. <br>专利： <br>1.治疗葡萄糖和或脂质代谢紊乱的药物和治疗葡萄糖和或脂质代谢紊乱的方法（美国专利），专利授权号：132257-00102. <br>2.Nogo-B抑制剂在制备治疗糖脂代谢紊乱药物中的应用和治疗糖脂代谢紊乱的药物，公开。
研究领域	<br>研究方向：代谢疾病（肝脏疾病、心血管疾病）的药理学和分子机理研究。 <br>招生方向：欢迎对基础医学和代谢疾病、药理学和分子靶点研究方向感兴趣的生物学、生物技术、药学、生物信息学、食品科学等相关专业的同学报考硕士研究生，一起发现疾病领域的未知。	科研项目	<br>1.国家自然科学基金青年项目，在研，主持。 <br>2.安徽省自然科学基金青年项目，在研，主持。 <br>3.合肥工业大学学术新人提升计划A项目，结题，主持。 <br>4.合肥工业大学学术新人提升计划B项目，在研，主持。 <br>5.企业合作委托项目，编号W2022JSFW0781，在研，主持。 <br>6.企业合作委托项目，编号W2022JSFW0883，在研，主持。 <br>7.产学研合作项目，编号W2023JSFW0071，在研，主持。 <br>8.产学研合作项目，编号W2023JSFW0567，在研，主持。 <br>9.复方中药创新数智研发，编号W2024JSFW0169，在研，主持。
荣誉奖项	<br>1.2018年中华医学科学技术奖三等奖“动脉粥样硬化干预靶点与机制研究”。 <br>2.2018年第十四届全国脂质与脂蛋白学术会议青年优秀论文大赛奖。 <br>3.2018年美国Experimental Biology 2018学术会议 ASBMB Travel Award。 <br>4.2019年动脉粥样硬化干预靶点与机制研究中华医学会科技奖三等奖。 <br>5.2019年南开大学博士研究生国家奖学金、博士研究生一等奖学金。 <br>6.2020年安徽省细胞生物学会口头报告一等奖。 <br>7.2022年安徽省病理生理学心血管疾病专业委员会优秀墙报特等奖。

硕士生导师