以通讯作者共发表研究论文60余篇,包括Nature Chem. Biol.、Nature Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、JACS Au、CCS Chem.等,
近年来主要代表作如下:
1.Zhao R., Shi P., Cui J. B., Shi C. W., Wei X. X., Luo J., Xia Z. M., Shi W. W., Zhou Y. X., Tang J. H., Tian C. L., Meininghaus M., Bierer D., Shi J.*, Li Y.-M.*, Liu L.*, Single-Shot Solid-Phase Synthesis of Full-Length H2 Relaxin Disulfide Surrogates. Angew. Chem. Int. Ed. 2023, 62, e202216365.
2.Chu, G. C.; Li, Y.-M.* Lighting up kinase contacts in situ. Nature Chem. Biol. 2024, 20, 544.
3.Wang, Y.; Chen, J. N.; Hua, X.; Meng, X. B.; Cai, H. Y.; Wang, R. T.; Shi, J.; Deng, H. T.; Liu, L.; Li, Y.-M.* Photocaging of Cell-permeable Activity-based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy. Angew. Chem. Int. Ed. 2022, 61, e202203792.
4.Liang, L. J.; Wang, Y.; Hua, X.; Yuan, R.; Xia, Q.; Wang, R. T.; Li, C.; Chu, G. C.; Liu, L.*; Li, Y.-M.* Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time Resolved Monitoring of Substrate Ubiquitination in Live Cells. JACS Au 2023, 3, 2873
5.Zheng, Q. Y.; Wang, T.; Chu, G. C.; Zuo, C.; Zhao, R.; Sui X.; Ye, L.; Yu, Y., Chen, J Zhang, W.; Deng, H.; Shi, J.; Pan, M.*; Li, Y.-M.*; Liu, L.* An E1-Catalyzed Chemoenzymatic Strategy to Isopeptide-N-Ethylated Deubiquitylase-Resistant Ubiquitin Probes, Angew. Chem. Int. Ed. 2020, 59, 13496.
6.Wang, Y.; Chen, C. C.; Meng, X.; Fan, J.; Pan, M.; Chen, J; Deng, H.; Shi, J.*; Liu, L.; Li, Y.-M.* Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO-Chain Specific Interacting Proteins. CCS Chem. 2020, 3, 1157.
7.Chu, G. C.; Pan, M.; Li, J.; Liu, S.; Zuo, C.; Tong, Z.-B.; Bai, J.-S.; Gong, Q.; Ai, H.; Fan, J.; Meng, X.; Huang, Y.-C.; Shi, J.; Deng, H.; Tian*, C.; Li, Y.-M.*; Liu, L.* Cysteine-Aminoethylation Assisted Chemical Ubiquitination of Recombinant Histones, J. Am. Chem. Soc. 2019, 141, 3654.
8.Li, Y. T.; Yi, C.; Chen, C. C.; Lan, H.; Pan, M.; Zhang, S. J.; Huang, Y. C.; Guan, C. J.; Li, Y.-M.*; Yu, L.*; Liu, L.* A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation. Nature Commun. 2017, 8, 14846.
9.Zhao, R.; Shi, P.; Chen, J. Y; Sun, S. S.; Chen, J. N.; Cui, J. B.; Wu, F. M.; Fang, G. M.; Tian, C. L.; Shi J.; Bierer, D.; Liu L.; Li, Y. M.* Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond. Chem. Sci. 2020, 11, 7927.
10.Tang, X. L. ; Pan, M.; Zheng, Y.; Gao, S.; Liang, L. J., Li, Y.-M.* Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin. Chem. Sci. 2017, 8, 6881.
专利
1.一种新型环状聚精氨酸穿膜肽分子及其合成方法和应用,专利授权号:202110526684.9
2.一种简易合成泛素探针Ub-Rho110-Gly的方法,专利授权号:201910179861.3
3.一种用于二泛素合成的新型辅基连接臂及其合成方法和应用,专利授权号:201910025364.8
4.一种环保型正交保护的二氨基二酸类化合物、其制备方法及其应用,专利授权号:201710498209.9
著作
1.《化学生物学实验》,中国科学技术大学出版社 编委