硕士生导师

    • 姓名:王玉
    • 职务:
    • 职称:讲师、硕导
    • 所属系:药物科学与工程系
    • 邮箱:yuwang@hfut.edu.cn
    • 办公地点:食生楼1111室
  • 个人简介
  • 研究领域
  • 科研项目
  • 学术成果
  • 荣誉奖项

学习经历:

20139-20176月            合肥工业大学                   学士

20179-20236月            中国科学技术大学               博士

工作经历:

202311-至今             合肥工业大学                  讲师


职务: 职称: 讲师、硕导
所属系: 药物科学与工程系 邮箱: yuwang@hfut.edu.cn
办公地点: 食生楼1111室 学术成果 <br>以第一/通讯作者(共同)在Nature Commun.、 J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、CCS Chem.、Chem. Comm. 等期刊发表研究论文10余篇。
<br>1.Y. Wang, J. Fan, X. Meng, Q. Shu, Y. Wu, G. C. Chu*, R. Ji, Y. Ye, X. Wu, J. Shi, H. Deng, L. Liu*, Y.-M. Li*. Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells. Nat Commun. 2025, 16, 415.
<br>2.Y. Wang, L. Liu, Q. Zheng, Y. Wu, Z. Su, R. Yuan, Q. Xia, B, Wang, Y. Yu*, Y.-M. Li*. Synergizing Structure-Guided Photocaged Linear Diubiquitin-Dha with Biotinylated Linear-Fab for Time-Resolved Profiling of Interactors in Living Cells. J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c15159.
<br>3.Y. Wang, J. Chen, X. Hua, X. Meng, H. Cai, R. Wang, J. Shi, H. Deng, L. Liu, Y.-M. Li*. Photocaging of Activity-Based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy. Angew. Chem. Int. Ed. 2022, 61, e202203792.
<br>4.L. Liu, P. Li, S. Yang, D. Yan, B. Wang, Y.-M. Li*, Y. Wang*. Acetylacetone-Modified Ubiquitin C-Terminus Enables Specific Capture of Sulfenylated Deubiquitinases. Chem Commun. 2026, DOI: 10.1039/D5CC05543A.
<br>5.Q. Xia, X. Meng, Y. Wang*, R. Yuan, P. Li, L. Liu, Y.-M. Li*. A cell-permeable Ub-Dha probe for profiling E1-E2-E3 enzymes in live cells. Chem Commun. 2024, 60, 4342-4345.
<br>6.P. Li, X. Han, B. Wang, Y. Guo, Y. Wang*, Y.-M. Li*. Efficient Synthesis of Cleavable CPP-cargo Conjugate via Low-equivalent of CPP Activated by 2,2’-dithiodipyridine. ChemBioChem. 2025, 26, e202500032.
<br>7.L. Liu, B. Wang, S. Yang, W. Wang, Y. Wang*, Y.-M. Li*. Semi-synthesis of functionalized cell-permeable ubiquitin probes via SrtA-mediated ligation. Org. Biomol. Chem. 2025, 23, 3459.
<br>8.D. Yang, B. Wang, Z. Song, J. Tang, N. Wang, J. Wang*, Y. Wang*, Y.-M. Li. One-step solid-phase synthesis of activated cell-penetrating peptides for cytosolic delivery of protein. Tetrahedron Lett. 2024, 153, 155385.
<br>9.J. Chen, Y. Wang*, R. Wang, R. Yuan, G-C. Chu *, Y.-M. Li*. Chemical synthesis of on demand-activated SUMO-based probe by a photocaged glycine-assisted strategy. Bioorg. Med. Chem. Lett. 2023, 94, 129460.
<br>10.Y. Wang, C. Chen, X. Meng, J. Fan, M. Pan, J. Chen, H. Deng, J. Shi*, L. Liu, Y.-M. Li*. Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO Chain-Specific Interacting Proteins. CCS. Chem. 2020, 2, 1157-1168.
11.Y. Wang, Q. Xia, X. Hua, Y. Guo, J. Shi*, Y.-M. Li*. Semi-synthesis of biotin-bearing activity-based ubiquitin probes through sequential enzymatic ligation, N-S acyl transfer and aminolysis reaction. Chin. Chem. Lett. 2023, 34, 108010.
L. J. Liang#, Y. Wang#, X. Hua#, R. Yuan, Q. Xia, R. Wang, C. Li, G. Chu, L. Liu*, Y.-M. Li*. A cell-permeable stimuli-responsive ubiquitin probe for time-resolved monitoring of substrate ubiquitination in live cells. JACS Au 2023, 3, 2873-2882. (#: equal contribution)
研究领域 <br>研究方向聚焦翻译后修饰光激活蛋白工具的化学构建与在体应用,形成 “探针设计 - 高效递送 - 功能筛查” 的完整体系:
<br>1)“光笼”蛋白探针设计与合成;
<br>2)合成蛋白工具的活细胞递送;
<br>3)翻译后修饰蛋白互作组的在体筛查。
科研项目 <br>1.国家自然科学基金青年项目,2025-2027,主持
<br>2.合肥工业大学学术新人提升计划A项目,2024-2025,主持
<br>3.合肥工业大学青年教师科研创新启动专项A项目,2024-2026,主持
荣誉奖项 <br>第一届化学生物学研究生前言论坛优秀墙报奖
<br>第二十届化学与材料科学研究生中文学术年会三等奖

上一条:操小栋 下一条:扈莹莹

关闭

电话:0551-62901285邮箱:spxy@hfut.edu.cn

邮编:230601地址:安徽省合肥市经济技术开发区大学城翡翠路420号

扫一扫

学院官方公众号