  | - 姓 名：
- 张弦
|
- 职 称：
副教授、硕士生导师
|
- 职 务：
- 教师
|
- 所属系：
- 食品科学与工程系
|
- 邮 箱：
zhangxian@hfut.edu.cn; zhangxian0426@hotmail.com |
- 电 话：
|
个人学习工作简介
2021.12 – 至今合肥工业大学食品与生物工程学院，副教授
2016.10 – 2021.10 美国哈佛大学医学院，博士后
2013.09 – 2016.06合肥工业大学食品与生物工程学院，食品科学与工程，博士
2010.09 – 2013.06 合肥工业大学食品与生物工程学院，生物学, 硕士
2006.09 – 2010.06 安徽师范大学生命科学学院，生物科学，学士
主要研究领域与方向
1.肥胖和相关代谢疾病（包括糖尿病和心血管疾病）的免疫-代谢调控
2.细胞代谢稳态与营养调控
欢迎生物学、食品科学与工程、食品工程等专业学生报考。
近年承担的科研项目
2023.1 – 2025.12 国家自然科学基金青年项目，主持，在研
2022.3 – 2025.3 合肥工业大学人才引进启动经费，主持，在研
2022.01 – 2023.12 海南医学院急救与创伤研究教育部重点实验室开放基金，主持，在研
2018.07 – 2020.09 American Heart Association (AHA) 美国心脏协会post-doctoral fellowship，主持，结题
获奖情况
2022年安徽省高层次人才引才资助
2020年度布莱根妇女医院心内科Lerner Symposium 学术海报大赛三等奖
2015年博士研究生国家奖学金
2015年安徽省细胞生物学会会员代表大会暨学术交流会三等奖
著作论文（代表作）
1) Zhang X., Luo S., Wang M., Huang Q., Fang W., Li J., Liu T., Zhang Y., Deng Z., Liu CL., Guan S., Ayala JE., Flavell RA., Kulkarni RN., Libby P., Guo J., Liu Z. and Shi GP. IL18 signaling causes islet beta cell development and insulin secretion via different receptors on acinar and beta cells. Developmental Cell. 2022;57(12):1496-511 e6. 2 (Impact factor: 13.417，中科院一区Top)
2) Zhang X., Luo S., Wang M., Cao Q., Zhang Z., Huang Q., Li J., Deng Z., Liu T., Liu CL., Meppen M., Vromman A., Flavell RA., Hotamisligil GS., Liu J., Libby P., Liu Z. and Shi GP. Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation. Nature Communications. 2022;13(1):7582. (Impact factor: 17.694，中科院一区Top)
3) Zhang Z., Wang J., Lin Y., Chen J., Liu J., and Zhang X. Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues. Critical Reviews in Food Science and Nutrition. 2022:1-15. (Impact factor: 11.208，中科院一区Top)
4) Wang J., Zhang Z., Lin Y., Chen J., Wang F., Wang L., Liu J., Zhang X. Diet supplementation of luteolin before fatty liver formation improves hepatic steatosis in obese mice by inhibiting visceral adipose tissue lipolysis. Molecular Nutrition & Food Research 2023: 2200478. (Impact factor: 6.575，中科院二区)
5) Zhang Y.#, Liu T.#, Deng Z.#, Fang W.#, Zhang X.#, Zhang S., Wang M., et al. Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils. Advanced Science 2023:e2206958. (并列一作) (Impact factor: 17.521，中科院一区Top)
6) Zhang X., Li J., Luo SY., Wang MJ., Huang Q., Deng ZY., Febbo C., Daoui A., Liew PX., Sukhova GK., Metso J., Jauhiainen M., Shi GP., Guo JL. IgE contributes to atherosclerosis and obesity by affecting macrophage polarization, macrophage protein network, and foam cell formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020; 40: 597-610. (Impact factor: 10.514，中科院一区Top)
7) Zhang X., Wang X., Yin H., Zhang L., Feng A., Zhang QX., Lin Y., Bao B., Hernandez LL., Shi GP., Liu J. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Reports. 2019; 28(3): 792-803. (Impact factor: 9.995，中科院一区Top)
8) Zhang X., Zhou Y., Yu X., Huang Q., Fang WQ., Li J., Bonventre JV., Sukhova GK., Libby P., Shi GP. Differential roles of cysteinyl cathepsins in TGF-β signaling and tissue fibrosis. iScience. 2019; 19: 607-622. (Impact factor: 6.107，中科院二区)
9) Zhang X., Huang Q., Wang X., Deng Z., Li J., Yan X., Jauhiainen M., Metso J., Libby P., Liu J., Shi GP. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2019; 1865(6):1690-1700 (Impact factor: 6.633，中科院二区)
10) Zhang X., Luo SY., Wang MJ., Shi GP. Cysteinyl cathepsins in cardiovascular diseases. Biochimica et Biophysica Acta - Proteins and Proteomics. 2020; 1868(4):140360 (Impact factor: 4.125，中科院三区)
11) Zhang X., Zhang QX., Wang X., Zhang L., Qu W., Bao B., Liu CA., and Liu J. Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1alpha pathway-mediated mechanism. International Journal of Obesity. 2016; 40(12): 1841-1849. (Impact factor: 5.551，中科院二区)
12)Dong J.#, Zhang X.#, Zhang L., Bian HX., Xu N., Bao B., and Liu J. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1. Journal of Lipid Research. 2014; 55(3):363-374. (并列一作) (Impact factor: 6.676，中科院二区)
