副教授/副研究员
您的当前位置:首页  师资队伍  员工名录  副教授/副研究员
徐建国
发布时间:2021-09-30    阅读次数: 3657
姓 名:
徐建国
职 称:

副教授

       职 务:        
所属系:
食品科学与工程系
邮 箱:
jgxu0816@163.comjgxu-sfse@hfut.edu.cn
电 话:
 13866783196
个人学习工作简介

工学博士,副教授,硕士生导师,毕业于福州大学,研究方向聚焦药品、食品和疾病标志物分析检测,通过利用核酸扩增分子诊断、核酸组装及光电分析纳米生物传感技术,发展了一系列检测新方法。累计共发表SCI论文50余篇(https://orcid.org/0000-0002-0187-2623),其中第一作者和通讯作者论文近40篇,总IF300,中科院一区Top论文20余篇,自然指数刊物4篇,研究成果发表在主流刊物BiomaterialsAnalytical ChemistryBiosensors and BioelectronicsJournal of Hazardous MaterialsJournal of Agricultural and Food ChemistryFood ChemistryChemical CommunicationAcs SensorsTheranosticsSensors & Actuators: B. Chemical,参编中英文专著2部,授权专利1项,申请发明专利3项,参与制定标准一项,获批主持国家青年基金,省基金、省重点研发计划,中国博士后基金等多项省部级项目。

主要研究领域与方向

食品安全危害物、疾病标志物增敏分析检测

目前承担的科研项目

[1] 国家自然科学基金青年科学基金,2019.01-2021.12,主持

[2] 安徽省重点研发计划,2021.01-2023.12,合作主持

[3] 安徽省重点研发计划项目,2020.01-2022.12主持

[4] 安徽省自然科学基金青年基金项目2019.07-2021.06,主持

[5] 中国博士后科学基金面上项目,2019.06-2021.01,主持

[6] 国家重点实验室开放基金项目2019.04-2021.03,主持(经费到校)

[7] 合肥工业大学学术新人提升B计划,2019.04-2020.12,主持

[8] 合肥工业大学学术新人提升A计划,2018.05-2019.12,主持(结题)

[9] 合肥工业大学科研启动基金2017.06-2020.06,主持

代表研究成果

一、期刊论文(通讯作者和第一作者):

[1] Xinlei Zhang, Jianguo Xu*, Xiuguang Xing, Li Yao, Huijie Shang, Wei Chen*. Framework nucleic acid-wrapped protein-inorganic hybrid nanoflowers with three-stage amplified fluorescence polarization for terminal deoxynucleotidyl transferase activity biosensing. Biosensors and Bioelectronics, 2021, 193: 113564

[2] Jianguo Xu*, Zhi Li, Yumei Li, Yusheng Lu, and Jie Wang*. Activation of palindromes on a degradable modular grafting probe enables ultrasensitive detection of microRNAs. Chemical Communications, 2021, 57, 5941-5944

[3] Xiaoming Ma, Zhen Wang, Xuan Hu, Jinghua Chen, Huifang Zhang, Xun Li, Fengyan Xie, Jianguo Xu*. Nanozyme catalysis-powered portable mini-drainage device enables realtime and universal weighing analysis of silver ions and silver nanoparticles. Journal of Hazardous Materials, 2021, 415, 125689 

[4] Xiuguang Xing, Li Yao, Chao Yan, Zhenlin Xu, Jianguo Xu*, Guodong Liu*, Bangben Yao* &Wei Chen*. Recent progress of personal glucose meters integrated methods in food safety hazards detection. Critical Reviews in Food Science and Nutrition. 2021: 1-14

[5] Xiaoming Ma, Shan He, Huifang Zhang, Xun Li*, Jun Xue, Xiaolin Fan, Yusheng Lu, Yiting Chen, Yanjie Zhang, and Jianguo Xu*. Delayed full opening of bumped switchable molecular probe enables repeated generation of target analogues for mix-to-signaling determination of microRNAs. Sensors & Actuators: B. Chemical, 2021, 327: 128875-128881

[6] Xinxin Wang, Jianguo Xu*, Panzhu Qin, Chao Yan, Guodong Liu, Wei Chen*. Self-assembly of a polythymine embedded activatable molecular beacon for one-step quantification of terminal deoxynucleotidyl transferase activity. Analytica Chimica Acta. 2021, 1141, 127-135 

[7] Jianguo Xu*, Xinxin Wang, Xinlei Zhang, Li Yao, Panzhu Qin, Yusheng Lu, Yiting Chen,Yanjie Zhang, Yehan Yan, Wei Chen*. Periodically programmed building and collapse of DNA networks enables an ultrahigh signal amplification effect for ultrasensitive nucleic acids analysis. Analytica Chimica Acta. 2021, 1150: 338221

[8] Wei Chen, Jun Teng, Li Yao, Jianguo Xu*, and Guodong Liu. Selection of specific DNA aptamers for hetero-sandwich based colorimetric determination of Campylobacter jejuni in food. Journal of Agricultural and Food Chemistry. 2020, 68, 31, 8455–8461

[9] Jie Wang, Shuhui Li, Jianguo Xu*, Yusheng Lu, Min Lin, Chaihung Wang, Chen Zhang, Guoxing Lin, Lee Jia*. Functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs. Chemical Communications, 2020, 56, 1681-1684

[10] Wei Chen*, Fen Cai, Qian Wu, Yuhan Wu, Bangben Yao, and Jianguo Xu*. Prediction, evaluation, confirmation, and elimination of matrix effects for lateral flow test strip based rapid and on-site detection of aflatoxin B1 in tea. Food Chemistry. 2020, 328, 127081

[11] Wei Chen*, Lijun Yang, Chao Yan, Bangben Yao, Jian-feng Lu, Jianguo Xu*, and Guodong Liu*. Surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wires-surrounded electroactive supernanostructures for ultrasensitive monitoring of morphine. ACS Sensors. 2020, 5, 8, 2644–2651

[12] Hongbo Li*, Mingbin Liu, Weihua Zhao, Jiamei Pu, Jianguo Xu*, Suqin Wang, Ruqin Yu*. Multi-channel collection of G-quadruplex transducers for amplified signaling of Pax-5 based on target-triggered split-to-intact remodeling of dual-G-rich duplex probe. Sensors & Actuators: B. Chemical, 2020, 311: 127913-127929

[13] Xiaoming Ma, Shan He, Ying Zhang, Jianguo Xu*, Huifang Zhang, Zhen Wang, Jun Xue, Xun Li,* Wenbo Yu*. Xiaolin Fan. Signal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozyme. Sensors & Actuators: B. Chemical, 2020, 311, 127933-127938

[14] Zhengrong Zhang, Shisheng Chen, Jianluan Ren, Fang Han, Xiaofeng Yu, Fang Tang, Feng Xue*, Wei Chen, Jielin Yang, Yuan Jiang, Hongmei Jiang, Bo Lv, Jianguo Xu*, Jianjun Dai. Facile construction of a Molecularly Imprinted Polymer based Electrochemical Sensor for the Detection of milk amyloid A. Microchimica Acta. 2020, 187, 642.

[15] Jianguo Xu#, Chao Yan#, Xinxin Wang, Bangben Yao, Jianfeng Lu, Guodong Liu*, Wei Chen*. Ingenious design of DNA concatamers and G-quadruplex wires assisted assembly of multi-branched DNA nanoarchitectures for ultrasensitive biosensing of miRNA. Analytical Chemistry, 2019, 91: 9747-9753

[16] Panzhu Qin, Li Yao, Jianguo Xu*, Guodong Liu, Wei Chen*. Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling. Chemical Communications, 2019,55, 14367-14370

[17] Li Yao, Yulin Li, Kewen Cheng, Daodong Pan, Jianguo Xu*, Wei Chen*,*Determination of 17β-estradiol by surface-enhanced Raman spectroscopy merged with hybridization chain reaction amplification on Au@Ag core-shell nanoparticles. Microchimica Acta, 2019, 186(2): 52.

[18] Xiaoming Ma, Zhen Wang, Shan He, Jingyi Zhao, Xiaoqi Lai*, Jianguo Xu*. L-cysteine modified gold nanoparticles for tube-based fluorometric determination of mercury(II) ions. Microchimica Acta, 2019, 186(9): 632. 

[19] Wei Chen, Chao Yan, Lin Cheng, Li Yao, Feng Xue, Jianguo Xu*. An ultrasensitive signal-on electrochemical aptasensor for ochratoxin A determination based on DNA controlled layer-by-layer assembly of dual gold nanoparticle conjugates, Biosensors and Bioelectronics, 2018,117: 845–851

[20] Jianguo Xu, Tingting Zheng, Jingqing Le, Lee Jia*, Stepwise nanoassembly of a single hairpin probe and its biosensing, Talanta, 2018, 187, 272-278

[21] Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs, Biomaterials, 2017, 120: 57-65 

[22] Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Jingqing Le, Tingting Zheng, Hongling Li, Lee Jia*. Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination, Biosensors and Bioelectronics, 2017, 94: 626-631 ,中科院一区,

[23] Jianguo Xu, Zai-Sheng Wu*, Yanru Chen, Tingting Zheng, Jingqing Le, Lee Jia*. Collapse of chain anadiplosis-structured DNA nanowires for highly sensitive colorimetric assay of nucleic acids, Analyst, 2017, 142: 613-620

[24] Jianguo Xu#, Tingting Zheng#, Jingqing Le, Lee Jia*, Long-stem shaped multifunctional molecular beacon for highly sensitive nucleic acids determination via intramolecular and intermolecular interactions based strand displacement amplification, Analyst, 2017, 142: 4438–4445

[25] Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Hongling Li, Jingqing Le, and Lee Jia*, Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene, Biomaterials, 2016, 100: 110-117

[26] Jianguo Xu, Zai-Sheng Wu*, Hongling Li, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Dual-cyclical nucleic acid strand-displacement polymerization based signal amplification system for highly sensitive determination of p53 Gene, Biosensors and Bioelectronics, 2016, 86: 1024-1030

[27] Jianguo Xu#, Jun Qian#, Hongling Li, Zai-Sheng Wu*, Weiyu Shen, Lee Jia*, Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids, Biosensors and Bioelectronics, 2016, 75: 41-47

[28] Jianguo Xu, Hongling Li, Zai-Sheng Wu*, Jun Qian, Chang Xue, Lee Jia*. Double-stem hairpin probe and ultrasensitive colorimetric detection of cancer-related nucleic acids, Theranostics, 2016, 6: 318-327

[29] Jianguo Xu, Haiyan Dong, Weiyu Shen, Sudan He, Hongling Li, Yusheng Lu, Zai-Sheng Wu*, Lee Jia*. New molecular beacon for p53 gene point mutation and significant potential in serving as the polymerization primer, Biosensors and Bioelectronics, 2015, 66: 504-511

[30] Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Huo Xu, Hongling Li, Lee Jia*. Cascade DNA nanomachine and exponential amplification biosensing, Biosensors and Bioelectronics, 2015, 73: 19-25

专著:

[1] Jianguo Xu, Li Yao, Lin Cheng, Chao Yan, and Wei Chen*. “Development of Aptamer-Based Electrochemical Methods.” Aptamers for Analytical Applications: Affinity Acquisition and Method Design, Willey publishing, 2018: 247-271.

[2]《食品安全学》,郑州大学出版社,编委201912

获奖情况
 

版权所有:合肥工业大学食品与生物工程学院  技术支持:南京苏迪
地址:安徽省合肥市经济技术开发区大学城翡翠路420号  邮编:230601  电话:0551-62901285  邮箱:spxy@hfut.edu.cn
皖ICP备12146036号-1  您是本站第
访客!
触碰右侧展开