教授/研究员
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王峰
发布时间:2018-09-11    阅读次数: 12784

姓 名:
王峰
职 称:
教授,博士生导师
个人主页
http://wangf.hfut.edu.cn/ 
所属系:
药物科学与工程系
邮 箱:
fengw420@hfut.edu.cn ;fengw420@gmail.com
电 话:
18655108700
个人学习工作简介

        王峰博士2007年毕业于合肥工业大学,获得学士学位;2012年毕业于中国科学技术大学合肥微尺度物质科学国家实验室(筹),获得博士学位,导师为王均教授。博士毕业后在加拿大滑铁卢大学(University of Waterloo,2012.11-2016.12016.4-2016.10)化学系及纳米技术研究所从事博士后研究,导师为Juewen Liu(刘珏文)教授。安徽省平台引进奖补项目(2016年)、安徽省“杰出青年”基金(2018年)获得者。2016年入选合肥工业大学“黄山青年学者”人才引进计划(教授,博士生导师)。王峰博士近年来一直致力于利用分析化学的手段研究纳米-生物界面的工作,在纳米材料与脂质体、细胞膜、核酸、免疫屏障的相互作用等领域取得了丰硕的研究成果。迄今,已在国际学术期刊J. Am. Chem. Soc.Angew.Chem. Int. Ed.Adv. Mater.Nano Lett.ACS NanoSmallBiomaterialsChem. Commun.NanoscaleAnal. Chem.等发表55篇学术论文。其中,以第一、共同第一和通讯作者身份在J. Am. Chem. Soc.(1篇),Angew. Chem. Int. Ed.(1篇)Adv. Mater.(2篇),ACS Nano(3篇)等国际期刊上发表31篇学术论文。研究工作开始受到国内外同行专家的关注,迄今所有论文共被他引3400余次6篇论文他引超过100次(单篇最高他引次755)。目前承担基金包括国家自然科学基金面上项目两项、国家自然科学基金青年基金一项、安徽省自然基金等。

主要研究领域与方向

主要研究方向集中在纳米-生物界面,包括:
(1)纳米材料与细胞膜相互作用的调控及其在药物(基因)传递中的应用;
(2)高效低毒抗肿瘤纳米药物的研制及其作用机制的研究;
(3)纳米材料的毒理学评价;
(4)纳米技术在现代农业中的应用。

代表性研究成果

工作一:系统地研究了无机纳米材料与脂质体的相互作用及其在药物传递中的应用(Adv. Mater. 2013, 25, 4087; Nanoscale 2013, 5, 12375; J. Am. Chem. Soc. 2015, 137, 11736; Angew. Chem. Int. Ed. 2016, 55, 12063; Nanoscale 2015, 7, 15599; Nanoscale 2015, 7, 15599; ACS Appl. Mater. Interfaces 2017, 9, 17736; Langmuir 2018, 34, 6628; Langmuir 2018, 34, 9337; Langmuir 2019, 35, 1672; ACS Nano 2019, 13, 11967; Adv. Mater. Interfaces 2021, 8, 2101605; Anal. Chim. Acta 2021, 1180, 338856; ACS Nano 2022

工作二:构建了对肿瘤细胞内微环境响应的纳米药物载体系统,用于克服肿瘤细胞的耐药性(ACS Nano 2011, 5, 3679; Bioconjugate Chem. 2011, 22, 1939
工作三:构筑核酸/核酸碱基为配体的金属配合物及其在分子识别等方面的应用(Chem. Commun. 2013, 49, 9482; Nanoscale 2014, 6, 7079; Anal. Chem. 2013, 85, 12144; Biosens. Bioelectron. 2019, 142, 111531; Biosens. Bioelectron. 2020, 143, 112310; Anal. Chem. 2021, 93, 3209
工作四:系统地研究了纳米颗粒对雄性ICR小鼠的生殖毒性(Small 2013, 9, 1708; Nano Lett. 2013, 13, 2477

工作五:纳米技术在现代农业中的应用(Adv. Mater. 2022, 34, 2106945

目前承担科研项目

国家自然科学基金面上项目,亲水头部反转脂质与生物-纳米界面作用过程的机制、调控及生物医学应用,3197131420201月~202312主持

国家自然科学基金面上项目纳米材料对脂质体相行为和流动性影响的基础研究,3157102320161月~201912主持

国家自然科学基金青年科学基金项目DNA在脂质体、纳米金表面杂交动力学的研究及生物应用,8150158720161月~201812主持

安徽省重点研究与开发计划国际科技合作专项,基于多模态影像的新型脂质体制剂在实体瘤EPR效应中的研究,202104b1102001520211~202312主持

安徽省自然科学基金杰青项目,20187月~20216主持

获奖情况

安徽省平台引进奖补项目2016

安徽省自然科学基金杰青项目2018

美国通用电器(GE)基金会科技创新一等奖(2011

发表的论文、专利与著作(代表作)

[31] Z. F. Wang, Y. Yan, C. Li, Y. Yu, S. Cheng, S. Chen, X. J. Zhu, L. P. Sun, W. Tao, J. W. Liu, F. Wang*, Fluidity-guided assembly of Au@Pt on liposomes as a catalase-powered nanomotor for effective cell uptake in cancer cells and plant leaves, ACS Nano, 2022, accept.

[30] Y. Yu, Z. F. Wang, S. C. Wu, C. M. Zhu, X. S. Meng, C. Li, S. Cheng, W. Tao, F. Wang*, A glutathione-sensitive nanoglue platform with effective nucleic acids gluing onto liposomes for photo-gene therapy. ACS Applied Materials & Interfaces, 2022, 14, 25126-25134.

[29] L. P. Sun, Y. Yan, S. Chen, Z. J. Zhou, W. Tao, C. Li*, Y. Feng*, F. Wang*, Co-N-C single-atom nanozymes with oxidase-like activity for highly sensitive detection of biothiols. Analytical and Bioanalytical Chemistry, 2022, 414, 1857-1865.

[28] Y. Yan, X. Zhu, Y. Yu, C. Li, Z. Zhang*, F. Wang*, Nanotechnology strategies for plant genetic engineering. Advanced Materials, 2022, 34, 2106945.

[27] S. Chen, Y. Yan, Y. Yu, Z. F. Wang, X. J. Zhu, L. P. Sun, C. Li, F. Wang*, Ferric ions as a catalytic mediator in metal-EGCG network for bactericidal effect and pathogenic biofilm eradication at physiological pH. Advanced Materials Interfaces, 2021, 8, 2101605.

[26] L. P. Sun, C. Li, Y. Yan, Y. Yu, H. Zhao, Z.J. Zhou, F. Wang*, Y. Feng*, Engineering DNA/Fe-N-C single-atom nanozymes interface for colorimetric biosensing of cancer cells. Analytica Chimica Acta, 2021, 1180, 338856.

[25] P. P. Deng, Y. Y. Pei, M. L. Liu, W. Z. Song, M. R. Wang, F. Wang*, C. X. Wu, L. Xu*, A rapid “on-off-on” mitochondria-targeted phosphorescent probe for selective and consecutive detection of Cu2+ and cysteine in live cells and zebrafish. RSC Advances, 2021, 11, 7610-7620.

[24] H. Li, M. L. Li, Y. C. Yang, F. Wang, F. Wang*, C. Li*, Aptamer-Linked CRISPRCas12a-Based Immunoassay. Analytical Chemistry, 2021, 93, 3209-3216.

[23] J. Y. Huang, M. Jian, S. H. Chen, S. Y. Zhang, T. Liu*, C. Li*, F. Wang*, A soft metal-polyphenol capsule-based ultrasensitive immunoassay for electrochemical detection of Epstein-Barr (EB) virus infection. Biosensors and Bioelectronics, 2020, 143, 112310.

[22] Y. C. Ma, Y. X. Zhang, X. Q. Li, Y. Y. Zhao, M. Li, W. Jiang, X. F. Tang, J. X. Dou, L. G. Lu, F. Wang*, Y. C. Wang*, Near-infrared II phototherapy induces deep tissue immunogenic cell death and potentiates cancer immunotherapy. ACS Nano, 2019, 13, 11967-11980.

[21] H. Wang, H. Li, Y. Huang, M. H. Xiong, F. Wang*, C. Li*, A label-free electrochemical biosensor for highly sensitive detection of gliotoxin based on DNA nanostructure/MXene nanocomplexes. Biosensors and Bioelectronics, 2019, 142, 111531.

[20] X. S. Wang, X. Q. Li, H. Wang, X. H. Zhang, L. Zhang, F. Wang*, J. W. Liu*, Charge and coordination directed liposome fusion onto SiO2 and TiO2 nanoparticles. Langmuir, 2019, 35, 1672-1681.

[19] X. R. Liu, X. Q. Li, W. Xu, X. H. Zhang, Z. C. Huang, F. Wang*, J. W. Liu*, Sub-angstrom gold nanoparticle/liposome interfaces controlled by halides. Langmuir, 2018, 34, 6628-6635.

[18] Y. B. Li, F. Wang*, J. Liu*, Headgroup inversed liposomes: biointerfaces, supported bilayers and applications. Langmuir, 2018, 34, 9337-9348.

[17] S. Y. Li, F. Wang*, X. Q. Li, J. Chen, X. H. Zhang, Y. C. Wang*, J. W. Liu*, Dipole Orientation matters: Longer-circulating choline phosphate than phosphocholine liposomes for enhanced tumor targeting. ACS Applied Materials & Interfaces, 2017, 9, 17736-17744.

[16] F. Wang, X. H. Zhang, Y. B. Liu, Z. Y. Lin, B. W. Liu, J. W. Liu*, Profiling metal oxides with lipids: Magnetic liposomal nanoparticles displaying DNA and proteins. Angewandte Chemie International Edition, 2016, 55, 12063-12067.

[15] F. Wang, D. Curry, J. W. Liu*, Driving adsorbed gold nanoparticle assembly by merging lipid gel/fluid interfaces. Langmuir, 2015, 31, 13271-13274.

[14] F. Wang, J. W. Liu*, A stable lipid/TiO2 interface with headgroup inversed phosphocholine and a comparison with SiO2. Journal of the American Chemical Society, 2015, 137, 11736-11742.

[13] F. Wang, J. W. Liu*, Self-healable and reversible liposome leakage by citrate-capped gold nanoparticles probing initial adsorption/desorption induced lipid phase transition. Nanoscale, 2015, 7, 15599-15604.

[12] F. Wang, J. W. Liu*, Evaporation induced wrinkling of graphene oxide at the nanoparticle interface. Nanoscale, 2015, 7, 919-923.

[11] F. Wang, J. W. Liu*, Liposome supported metal oxide nanoparticles: interaction mechanism, light controlled content release and intracellular delivery. Small, 2014, 10, 3927-3931.

[10] F. Wang, J. W. Liu*, Platinated DNA oligonucleotides: new probes forming ultrastable conjugates with graphene oxide. Nanoscale, 2014, 6, 7079-7084.

[9] F. Wang, B. W. Liu, P. J. J. Huang, J. W. Liu*, Rationally designed nucleobase and nucleotide coordinated nanoparticles for selective DNA adsorption and detection. Analytical Chemistry, 2013, 85, 12144-12151.

[8] F. Wang, B. W. Liu, A. C. F. Ip, J. W. Liu*, Orthogonal adsorption onto nano-graphene oxide using different intermolecular forces for multiplexed delivery. Advanced Materials, 2013, 25, 4087-4092.

[7] F. Wang, P. J. J. Huang, J. W. Liu*, Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine. Chemical Communications, 2013, 49, 9482-9484.

[6] F. Wang, J. W. Liu*, Nanodiamond decorated liposomes as highly biocompatible delivery vehicles and a comparison with carbon nanotube and graphene oxide. Nanoscale, 2013, 5, 12375-12382.

[5] W. Q. Li, F. Wang, Z. M. Liu, Y. C. Wang, J. Wang*, F. Sun*, Gold nanoparticles elevate plasma testosterone levels in male mice without affecting fertility. Small, 2013, 9, 1708-1714.

[4] F. Wang, Y. C. Wang, S. Dou, M. H. Xiong, T. M. Sun, J. Wang*, Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano, 2011, 5, 3679-3692.

[3] F. Wang, R. Saran, J. W. Liu*, Tandem DNAzymes for mRNA cleavage: choice of enzyme, metal ions and the antisense effect. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 1460-1463.

[2] Y. C. Wang, F. Wang, T. M. Sun, J. Wang*, Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjugate Chemistry, 2011, 22, 1939-1945.

[1] F. Wang, Y. C. Wang, L. F. Yan, J. Wang*, Biodegradable vesicular nanocarriers based on poly(ε-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery. Polymer, 2009, 50, 5048-5054.

其他情况

欢迎具有化学、物理、生物、药学、医学、食品等背景的学生报考实验室研究生;

欢迎对科研有兴趣的本科生来实验室,参与课题;

有意向从事博士后研究的科研工作者,请直接与王峰教授邮件联系。

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