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杨静文
发布时间:2018-09-11    阅读次数: 846
姓 名:
杨静文
职 称:
讲师
职 务:

所属系:
药物科学与工程系
邮 箱:
jwyang@hfut.edu.cn
电 话:
 
个人学习工作简介

20177月至今               合肥工业大学 食品与生物工程学院 讲师

20159-20171月   奥胡斯大学 生物化学工程系

20119-20176月   吉林大学 生命科学学院 硕博连读

20079-20116月   吉林农业大学 农学院 本科
主要研究领域与方向

基于定向进化的酶的分子改造、酶催化及应用

目前承担的科研项目

1、安徽省自然科学基金,1908085QC130,基于分子改造的右旋糖酐蔗糖酶受体结合位点优化研究, 2019/07- 2021/06,在研,主持。

2、合肥工业大学学术新人提升计划项目,基于理性设计的右旋糖酐蔗糖酶受体结合位点的分子改造, 2019/04-2020/12,在研,主持。
获奖情况

12017年吉林大学校级优秀博士论文

2、安徽省生物工程学会2017年度优秀青年学者三等奖

32017年“生物技术与健康产业发展”研讨会优秀论文奖
著作论文专利

科研论文:

(1) Yuxin Zhang#; JingwenYang#*; Xiaoqin Yu; Xueqin Hu; Hongbin Zhang*. Engineering Leuconostoc mesenteroides dextransucrase by inserting disulfide bridges for enhanced thermotolerance, Enzyme and Microbial Technology, 2020.139: 109603.

(2)Hao Wu; Ding-cong Shang-guan; Qi-meng Lu; Xue-qin Hu; Jingwen Yang*; Hong-bin Zhang*. Oxidation of dextran using H2O2 and NaClO/NaBr and their applicability in iron chelation, International Journal of Biological Macromolecules, 2020. 144: 615-623.
 (3) Jinghan Hua; Hongbin Zhang; Hao Wu; Jiadong Wang; Xueqin Hu; Jingwen Yang*. Discovery and Characterization of a Novel Method for Effective Improvement of Cyclodextrin Yield and Product Specificity, Chemical Research in Chinese Universities, 2019. 35: 708-713.

(4) Mengqi Li; Hongbin Zhang*; Yao Li; Xueqin Hu; Jingwen Yang*. The thermoduric effects of site-directed mutagenesis of proline and lysine on dextransucrase from Leuconostoc mesenteroides 0326, International Journal of Biological Macromolecules, 2018. 107: 1641~1649.
 (5) Jingwen Yang; Renjun Gao; Ye Zhou; Sampson Anankanbil; Jingbo Li; Guiqiu Xie*; Zheng Guo*. β-Glucosidase from Thermotoga naphthophila RKU-10 for exclusive synthesis of galactotrisaccharides: Kinetics and thermodynamics insight into reaction mechanism, Food Chemistry, 2018. 240: 422~429.
 (6) Jingwen Yang; Qi Wang; Ye Zhou; Jingbo Li; Renjun Gao*; Zheng Guo*, Engineering T. naphthophila β-glucosidase for enhanced synthesis of galactooligosaccharides by site-directed mutagenesis, Biochemical Engineering Journal, 2017. 127: 1~8.
 (7) Jingwen Yang; Bianca Pérez; Sampson Anankanbil; Jingbo Li; Ye Zhou; Renjun Gao*; Zheng Guo*. Valorizing Dairy Waste: Thermophilic Biosynthesis of a Novel Ascorbic Acid Derivative, Journal of Agricultural and Food Chemistry, 2017. 65: 9087~9093.
 (8) Jingwen Yang; Bianca Pérez; Sampson Anankanbil; Jingbo Li; Renjun Gao*; Zheng Guo*. Enhanced Synthesis of Alkyl Galactopyranoside by Thermotoga naphthophila β-Galactosidase Catalyzed Transglycosylation: Kinetic Insight of a Functionalized Ionic Liquid-Mediated System, ACS Sustainable Chemistry & Engineering. 2017. 5(2) : 2006~2014.

(9) Jingwen Yang; Xiaochen Chen; Dahai Yu; Renjun Gao*. Microwave-assisted synthesis of butyl galactopyranoside catalyzed by β-galactosidase from thermotoga naphthophila RKU-10, Process Biochemistry. 2016.51(1): 53-58.

(10) Jingwen Yang; Xiangjun Di; Man Wang; Renjun Gao*. Gene Clone and Characterization of a Novel Thermostable β-Galactosidase with Transglycosylation Activity from Thermotoga naphthophila RUK-10, Chemical Research in Chinese Universities. 2015. 31(4):564-568.

(11) Yao Li; Lanhua Liu; Xiaoqin Yu; Yuxin Zhang; Jingwen Yang; Xue-qin Hu; Hongbin Zhang*. Transglycosylation Improved Caffeic Acid Phenethyl Ester Anti-Inflammatory Activity and Water Solubility by Leuconostoc mesenteroides Dextransucrase, Journal of Agricultural and Food Chemistry, 2019. 67: 4505-4512.

(12) Tao Zeng; Xueqin Hu; Hao Wu; Jingwen Yang; Hongbin Zhang*. Microwave assisted synthesis and characterization of a novel bio-based flocculant from dextran and chitosan, International Journal of Biological Macromolecules, 2019. 131: 760-768.

(13) Shuang Chen; Hao Wu; Jinghan Hua; Jingwen Yang; Hongbin Zhang*; Xueqin Hu*. The effect of NaOH and NaClO/NaBr modification on the structural and physicochemical properties of dextran, New Journal of Chemistry, 2018. 42(8).

(14) Sampson Anankanbil; Bianca Pérez; Jingwen Yang; Chiranjib Banerjee; Zheng Guo*. A novel array of interface-confined molecules: Assembling natural segments for delivery of multi-functionalities, Journal of Colloid and Interface Science, 2017. 508: 230-236.

(15) Fansi Kong; Jingwen Yang; Zhen Zhen; Tingting Liang; Dongliang Zhu; Renjun Gao; Guiqiu Xie*. Gene cloning and molecular characterization of a β-glucosidase from Thermotoga naphthophila RUK-10: an effective tool for synthesis of galacto-oligosaccharide and alkyl galactopyranosides, Chemical Research in Chinese Universities,2015. 31: 774–780.

专利:

1、张洪斌; 花敬涵; 杨静文; 胡雪芹一种表达高特异性β环糊精糖基转移酶的基因工程菌及其构建方法和应用, 申请号: 201811617619.1, 申请日: 2018.12.28, 公开(公告): CN109706131A, 公开(公告)日: 2019-05-03.
 2
、张洪斌; 李瑶; 余晓琴; 张宇馨; 胡雪芹; 杨静文. 一种右旋糖酐蔗糖酶的糖基化应用以及将其用于制备咖啡酸苯乙酯糖苷的方法, 申请号: 201910395862.1, 申请日: 2019.5.14, 公开(公告)号: CN110117630A, 公开(公告)日: 2019-08-13.
 3
、张洪斌; 李梦绮; 李瑶; 胡雪芹;  杨静文一种表达耐热型右旋糖苷蔗糖酶的基因工程菌及其构建方法和用途, 申请号: 201710615998.X , 申请日: 2017.7.26, 公开(公告)号: CN107201332A, 公开(公告)日: 20170926, 主分类号: C12N1/21.


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