教授/研究员
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韩际宏
发布时间:2018-09-11    阅读次数: 3063

姓 名:
韩际宏
职 称:
教授,博导
职 务:

所属系:
药物科学与工程系
邮 箱:
hanjihong2015@hfut.edu.cn
电 话:

个人工作简介
韩际宏 博士,特聘教授、973计划首席科学家,合肥工业大学食品与生物工程学院教授、博士生导师,国家自然科学基金会评专家,科技部、卫计委国家重点研发计划评审专家,科技部国际合作项目、国家重大研究计划评审专家,国家科技奖励评审专家,中国生物化学与分子生物学会脂质与脂蛋白专业委员会常务委员。

韩际宏教授1987年毕业于南开大学化学系、理学学士,1989年毕业于南开大学高分子研究所、理学硕士,1995年毕业于美国康奈尔大学医学院(Cornell University Medical College)、理学博士。分别于1999年、2004年被康奈尔大学医学院血管生物学中心(Vascular Center of Cornell University Medical College)聘为助理教授、副教授。2007年全职回国,2009年入选“长江学者奖励计划”特聘教授。主要从事重大慢病防治研究,特别是脂质代谢异常所引起的动脉粥样硬化、糖尿病、脂肪肝等疾病发生发展过程中的分子生物学机制研究;结合胆固醇和脂代谢研究寻找预防、减少重大慢病发病的新机理和途径。近年来主持973计划、国家自然科学基金等项目十余项。目前已在国际一流刊物上以通讯作者等身份发表八十多篇论文并多次在国际学术大会作报告,总科学影响因子高于350点,被引用次数总计3000次以上,研究成果先后获中华中医药学会科学技术奖一等奖、教育部高等学校科学研究优秀成果自然科学二等奖、中华医学会科技奖三等奖等。

个人获奖

“中药大品种丹红注射液药效物质基础、作用机制、质量控制及产业化” 中华中医药学会科学技术奖一等奖,2015年,第四完成人

“动脉粥样硬化干预靶点与机制研究”,教育部高等学校科学研究优秀成果自然科学二等奖,2017年,第一完成人

“动脉粥样硬化干预靶点与机制研究”,中华医学会科技奖三等奖,2018年,第一完成人

  Acta Pharmacologica Sinica Outstanding Reviewer Award in 2016
近年主持科研项目

国家自然科学基金面上项目:激活miR-126信号通路介导MEK1/2抑制剂抗血管钙化,2020.1-2023.12,主持

政府间国际科技创新合作重点专项:Nogo-B表达在胆汁代谢与胆汁淤积中的病生理功能与机制研究,2018.4-2022.3,主持

国家自然科学基金面上项目:MetforminT0901317联用防治动脉粥样硬化的机理研究,2018.1-2021.12,主持

步长制药集团:龙生蛭胶囊对阿尔兹海默症的作用与机制研究,2018.5-2019.5,主持

步长制药集团:龙生蛭胶囊治疗缺血性脑卒中的作用与机制研究,2017.5-2018.5,主持

步长制药集团:脑心通胶囊类阿司匹林作用机制研究,2016.7-2017.10,主持

2012年以来发表的科研论文

1.Xu S, Wang Y, Yu M, Wang D, Liang Y, Chen Y, Liao C, Xie Z, Zhao B, Han J, Duan Y, Yang X. LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress. Biomedicine & Pharmacotherapy, 2020,123:109803.

2.Zhang S, Yu M, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao Q, Hu W, Hajjar DP, Zhu Y, Han J*, Duan Y*. Rosiglitazone alleviates -naphthylisothiocyanate-induced intrahepatic cholestasis in mice – The role of circulating 15d-PGJ2 and Nogo. British Journal of Pharmacology, 2020;177(5): 1041-1060.

3.Yang J, Liu L, Yang X, Duan Y, Zeng P, Yang S, Ma C, Li X, Han J, Chen Y. Combination of MEK1/2 inhibitor and LXR ligand synergistically inhibit atherosclerosis in LDLR deficient mice. Biochemical and Biophysical Research Communications 2019, doi: 10.1016/j.bbrc.2019.11.115.

4.Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y*, Chen Y*. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signalling, 2020, 65:109429. 

5.Wei Z, Zhao D, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J*, Yang X*. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-B-TNF- signaling pathway in a PPAR-dependent manner. Biochemical and Biophysical Research Communications 2019. 519: 854-860.

6.Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X*, Han J*. Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice. Biomedicine and Pharmacotherapy, 2019, 118:109389.

7.Xiao G, Lyu M, Wang Y, He S, Liu X, Ni J, Li L, Fan G, Han J, Gao X, Wang X, Zhu Y. Ginkgo flavonol glycosides or ginkgolides tend to differentially protect myocardial or cerebral ischemia-reperfusion injury via regulation of TWEAK-Fn14 signaling in heart and brain. Frontiers in Pharmacology. 2019;10:735.

8.Li Q, Chen Y, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, Chen Y, Duan Y, Han J*, Yang X*. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing endothelial inflammation and inactivating platelets. Pharmacological Research, 2019;144:167-180.

9.Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J*, Yang X*. LongShengZhi capsule reduces established atherosclerotic lesions in apoE deficient mice. Journal of Cardiovascular Pharmacology 2019;73:105-117.

10.Li S, Lv X, Cheng K, Tian Y, Huang X, Kong H, Duan Y, Han J, Liao C, Xie Z. Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2019;29:1090-1093

11.Cheng K, Li S, Lv X, Tian Y, Kong H, Huang X, Duan Y, Han J, Xie Z, Liao C. Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure. Bioorg Med Chem Lett. 2019;29:1012-1018.

12.Han J, Tan H, Duan Y, Chen Y, Zhu Y, Zhao B, Wang Y, Yang X. The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule. Pharmacological Research, 2019;141:409-417.

13.Liang Y, Han H, Liu L, Duan Y, Yang X, Ma C, Zhu Y, Han J, Li X, Chen Y. CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells. Oncogenesis (2018)7:98.

14.Liu Y, Wei Z, Zhang Y, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Gu J, Liu J, Han J, Yang X, Duan Y. Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. Journal of Lipid Research 2018;59:2287-2296 (封面论文并被美国生物化学与分子生物学学会新闻月刊ASBM Today专题报道).

15.Han H, Yang S, Liang Y, Zeng P, Liu L, Yang X, Duan Y, Han J, Chen Y. Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner. Biochemical and Biophysical Research Communications 2018;506:1040-1046. 

16.Variya BC, Bakrania AK, Chen Y, Han J, Patel SS. Suppression of abdominal fat and anti-hyperlipidemic potential of Emblica officinalis: Upregulation of PPARs and identification of active moiety. Biomedicine and Pharmacotherapy 2018;108:1274-1281

17.Liu L, Zeng P, Yang X, Duan Y, Zhang W, Ma C, Zhang X, Yang S, Li X, Yang J, Liang Y, Han H, Zhu Y, Han J*, Chen Y. Inhibition of vascular calcification—A new anti-atherogenic mechanism of DNA topoisomerase II inhibitors. Arteriosclerosis, Thrombosis and Vascular Biology 2018;38:2382-2395. 

18.Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y, Gao X, Li X, Duan Y, Han J*, Yang X*. NaoXinTong capsule inhibits carrageenan-induced thrombosis in mice. Journal of Cardiovascular Pharmacology 2018;72:49-59 

19.Yang, S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J*, Yang X*. NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice. Scientific Reports 2018;8:9158 

20.Ma C, Zhang W, Liu Y, Liu L, Yang X, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Miao QR, Zhu Y, Han J*, Chen Y*, Duan Y*. Functional interplay between LXR and AMPK reduces inhibits atherosclerosis tic lesions in apoE knockout mice-deficient mice—A new anti-atherogenic strategy. British Journal of Pharmacology 2018;175:1486-1503.

21.Owoicho Orgah J, Wang M, Yang X, Wang Z, Wang D, Zhang Q, Fan G, Han J, Qin G, Gao X, Zhu Y. Danhong Injection protects against hypertension-induced renal injury via down-regulation of myoglobin expression in spontaneously hypertensive rats. Kidney Blood Press Research 2018;43:12-24.

22.Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Yu M, Ma C, Gu J, Miao RQ, Hajjar DP, Han J*, Duan Y*. 25-Hydroxycholesterol induces its own production by activating cholesterol 25-hydroxylase expression in an LXR dependent mechanism. Journal of Lipid Research 2018;59:439-451.

23.Zhang W, Yang X, Chen Y, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao QR*, Han J*, Duan Y*. Activation of hepatic Nogo-B receptor expression—A new anti-liver steatosis mechanism of statins. BBA-Molecular Cell Biology of Lipid 2018;1863:177-190.

24.Chen X, Feng Y, Shen X, Pan G, Fan G, Gao X, Han J, Zhu Y. Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis. Journal of Ethnopharmacology 2018;211:358-365.

25.Lyu M, Yan C, Liu H, Chen X, Wang Y, Han J, Fan G, Zhu Y. Network pharmacology exploration reveals endothelial inflammation as a common target for coronary artery disease and stroke treatment by Danhong injection. Scientific Reports 2017;7:15427. 

26.Yang X, Orgah J, Wang D, Fan G, Jingyang H, Han J, Qin G, Gao X, Zhu Y. Danhong injection reduces vascular remodeling and up-regulates the Kallikrein-kinin system in spontaneously hypertensive rats. Scientific Reports 2017;7:4308. 

27.Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao Q, Han J*, Duan Y*. Activation of adiponectin receptor regulates proprotein convertase subtilisin/kexin type 9 expression and inhibits lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology 2017;37:1290-1300.

28.Yu M, Liu Y, Duan Y, Chen Y, Han J, Sun L, Yang X. Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis—a unique anti-oxidative stress mechanism in mice. Biochemical and Biophysical Research Communications 2017;484:56-63.

29.Yang X, Li Y, Sun L, Liu Y, Ma C, Chen Y, Tan H, Li Q, Li X, Wang Y, Duan Y, Zhao B*, Han J*. NaoXinTong enhances atorvastatin-reduced atherosclerosis while antagonizing atorvastatin-induced hepatic inflammation. Journal of Cardiovascular Pharmacology 2017;69:55-64.

30.He S, Zhao T, Guo H, Meng Y, Qin G, Goukassian DA, Han J, Gao X, Zhu Y. Coordinated activation of VEGF/VEGFR-2 and PPAR pathways by a multi-component Chinese medicine DHI accelerated recovery from peripheral arterial disease in type 2 diabetic mice. PLoS One. 2016;11:e0167305. 

31.Zhang K, Cai HX, Gao S, Yang GL, Deng HT, Xu GC, Han J, Zhang QZ, Li LY. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals. Oncotarget 2016;7:69436-69449.

32.Hu W, Zhang W, Chen Y, Rana U, Teng R, Duan Y, Liu Z, Zhao B, Foeckler J, Weiler H, Kallinger RE, Thomas MJ, Zhang K, Han J*, Miao QR*. Nogo-B receptor deficiency increases LXR nuclear translocation and hepatic lipogenesis. Hepatology 2016;64:1559-1576.

33.Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*. 2016. Inhibition of macrophage CD36 expression and cellular oxLDL accumulation by tamoxifen--A PPAR dependent mechanism. The Journal of Biological Chemistry 2016;291:16977-89 (封面论文) 

34.Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Yajun Duan*. 2016 Activation of PPAR and CD36 expression--the dual pathophysiological role of progesterone. The Journal of Biological Chemistry 2016;291:15108-18 

35.Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li LY, Miao QR, Hajjar DP, Duan Y*, Han J*. 2016. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport--an anti-atherogenic function of ERK1/2 inhibition. BBA-Molecular and Cell Biology of Lipid 2016;1861:1180-1191

36.Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. 2016. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene. Scientific Reports 2016;6:27295.

37.Yang M, Orgah J, Zhu J, Fan G, Han J, Wang X, Zhang B, Zhu Y. Danhong Injection attenuates cardiac injury induced by ischemic and reperfused neuronal cells through regulating arginine vasopressin expression and secretion. Brain Research 2016;1642:516-23.

38.Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X. JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. Oncotarget 2016;7:29387-99. 

39.Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y, Chen Y. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochemical and Biophysical Research Communications 2016;473:939-46. 

40.Liu M, Zhang W, Li X, Han J, Chen Y, Duan Y. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochemical and Biophysical Research Communications 2016;469;456-462

41.Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X*, Chen Y*. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology 2016;67:203-11

42.Yang X, Yao H, Chen Y, Sun L, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake. The Journal of Biological Chemistry 2015;290:21788-21799

43.Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J*, Duan Y*. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Scientific Reports 2015;5,11219; doi: 10.1038/srep11219 

44.Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang X, Duan Y, Han J*. Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II. The Journal of Biological Chemistry 2015;290:14418–14429 

45.Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE-/- mice. Journal of Cardiovascular Pharmacology 2015;66:189-95

46.Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. BBA-Molecular Basis of Diseases 2015;1852:1038-1048

47.Chen Y, Duan Y, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao QR, Xiang R, Hajjar DP, Han J*. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology 2015;35:948-959 

48.Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X*, Duan Y*. NaoXinTong inhibits the development of diabetic retinopathy in db/db mice. Evidence-Based Complementary and Alternative Medicine Volume 2015; Article ID 242517, 8 pages, http://dx.doi.org/10.1155/2015/242517

49.Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y*, Han J*. Inhibition of tumor growth by U0126 is associated with induction of interferon- production. International Journal of Cancer 2015;136:771-783 (封面论文)

50.Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y*, Han J*. Identification of interferon- as a new molecular target of liver X receptor. Biochemical Journal 2014;459:345-354 (专评论文: Biochemical Journal. 2014;459:e1-e3) 

51.Chen Y, Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y*. Danhong Injection inhibits the development of atherosclerosis in both Apoe-/- and Ldlr-/- mice. Journal of Cardiovascular Pharmacology 2014;63:441-452

52.Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*. Danhong injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin 2014;59:1366-1373

53.Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells 2013;31:2538-2550 

54.Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of GR and PPAR pathways. Biochemical Journal 2013;454:467-477 

55.Qiao L, Wu Q, Lu X, Zhou Y, Fernández-Alvarez A, Ye L, Zhang X, Han J, Casado M, Liu Q. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter. Biochemical Biophysical Research Communication 2013;432:643-649 

56.Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux---an LXR-dependent mechanism. BBA-Molecular and Cell Biology of Lipids 2013;1831:1134-1145 

57.Meng X, Zhang Y, Jia Z, Huo X, He X, Tian G, Wu M, Wang Z, Zhou X, Xiong S, Gao X, Wu Z, Han J, Zhao L, Wang P, Hong Z, Wang Q, Yin Z. A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis. Journal of Leukocyte Biology 2013;93:83-93

58.Chen Y, Duan Y*, Kang Y, Yang X, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J*. Activation of liver X receptor induces macrophage interleukin-5 expression. The Journal of Biological Chemistry 2012;287:43340-43350

59.Duan Y, Chen Y, Hu W, Li X, Zhou X, Yin Z, Kong D, Hajjar DP, Liu L, Liu Q, Han J*. PPAR activation by ligands and dephosphorylation induces PCSK9 and LDLR expression. The Journal of Biological Chemistry 2012;287:23667-23677

60.Hu W, Zhou X, Jiang N, Duan Y, Chen Y, Li X, Yin Z, He G, Yao Z, Zhu Y, Hajjar DP, Han J*. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis 2012;222:434-443

61.Zheng W, Wang Z, Song L, Zhao Q, Zhang J, Li D, Wang S, Han J, Zheng XL, Yang Z, Kong D. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials 2012;33:2880-2891

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